Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Jeon, Jaepyo [VerfasserIn]   i
 Bu, Fan [VerfasserIn]   i
 Sun, Guanghua [VerfasserIn]   i
 Tian, Jin-Bin [VerfasserIn]   i
 Ting, Shun-Ming [VerfasserIn]   i
 Li, Jun [VerfasserIn]   i
 Aronowski, Jaroslaw [VerfasserIn]   i
 Birnbaumer, Lutz [VerfasserIn]   i
 Freichel, Marc [VerfasserIn]   i
 Zhu, Michael X. [VerfasserIn]   i
Titel:Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke
Verf.angabe:Jaepyo Jeon, Fan Bu, Guanghua Sun, Jin-Bin Tian, Shun-Ming Ting, Jun Li, Jaroslaw Aronowski, Lutz Birnbaumer, Marc Freichel and Michael X. Zhu
E-Jahr:2021
Jahr:08 January 2021
Teil:volume:8
 year:2021
Fussnoten:Gesehen am 03.03.2021
Titel Quelle:Enthalten in: Frontiers in cell and developmental biology
Ort Quelle:Lausanne : Frontiers Media, 2013
Jahr Quelle:2021
Band/Heft Quelle:8(2021) Artikel-Nummer 618663, 17 Seiten
ISSN Quelle:2296-634X
Abstract:The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but their deregulation can also lead to cell damage. Recent studies have implicated complex roles of TRPC channels in neurodegenerative diseases including ischemic stroke. Brain ischemia reduces oxygen and glucose supply to neurons, i.e., Oxygen and Glucose Deprivation (OGD), resulting in [Ca2+]i elevation, ion dyshomeostasis, and excitotoxicity, which are also common in many forms of neurodegenerative diseases. Although ionotropic glutamate receptors, e.g., N-methyl-D-aspartate receptors, are well established to play roles in excitotoxicity, the contribution of metabotropic glutamate receptors and their downstream effectors, i.e., TRPC channels, should not be neglected. Here, we review the current findings about contributions of TRPC channels in neurodegenerative diseases, with a focus on OGD-induced neuronal death and rodent models of cerebral ischemia/reperfusion. TRPC channels play both detrimental and protective roles to neurodegeneration depending on the TRPC subtype and specific pathological conditions involved. When illustrated the mechanisms by which TRPC channels are involved in neuronal survival or death seem differ greatly, implicating diverse and complex regulation. We provide our own data showing that TRPC1/C4/C5, especially TRPC4, may be generally detrimental in OGD and cerebral ischemia/reperfusion. We propose that although TRPC channels significantly contribute to ischemic neuronal death, detailed mechanisms and specific roles of TRPC subtypes in brain injury at different stages of ischemia/reperfusion and in different brain regions need to be carefully and systematically investigated.
DOI:doi:10.3389/fcell.2020.618663
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3389/fcell.2020.618663
 Volltext: https://www.frontiersin.org/articles/10.3389/fcell.2020.618663/full
 DOI: https://doi.org/10.3389/fcell.2020.618663
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Calcium
 neurodegeneration
 Neurological Disease
 Neuronal Death
 Neuroprotection
 trpc4 knockout
K10plus-PPN:1750230674
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68706663   QR-Code
zum Seitenanfang