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| Verfasst von: | Shafi, Ayesha [VerfasserIn]  |
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| | McNair, Chris M. [VerfasserIn] |
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| | McCann, Jennifer J. [VerfasserIn] |
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| | Alshalalfa, Mohammed [VerfasserIn] |
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| | Shostak, Anton [VerfasserIn] |
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| | Severson, Tesa M. [VerfasserIn] |
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| | Zhu, Yanyun [VerfasserIn] |
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| | Bergman, Andre [VerfasserIn] |
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| | Gordon, Nicolas [VerfasserIn] |
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| | Mandigo, Amy C. [VerfasserIn] |
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| | Chand, Saswati N. [VerfasserIn] |
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| | Gallagher, Peter [VerfasserIn] |
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| | Dylgjeri, Emanuela [VerfasserIn] |
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| | Laufer, Talya S. [VerfasserIn] |
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| | Vasilevskaya, Irina A. [VerfasserIn] |
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| | Schiewer, Matthew J. [VerfasserIn] |
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| | Brunner, Michael [VerfasserIn] |
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| | Feng, Felix Y. [VerfasserIn] |
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| | Zwart, Wilbert [VerfasserIn] |
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| | Knudsen, Karen E. [VerfasserIn] |
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| Titel: | The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair |
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| Verf.angabe: | Ayesha A. Shafi, Chris M. McNair, Jennifer J. McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M. Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C. Mandigo, Saswati N. Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S. Laufer, Irina A. Vasilevskaya, Matthew J. Schiewer, Michael Brunner, Felix Y. Feng, Wilbert Zwart, Karen E. Knudsen |
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| E-Jahr: | 2021 |
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| Jahr: | 15 January 2021 |
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| Umfang: | 15 S. |
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| Teil: | volume:12 |
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| | year:2021 |
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| | elocationid:401 |
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| | pages:1-15 |
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| | extent:15 |
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| Fussnoten: | Gesehen am 03.03.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 401, Seite 1-15 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Mechanisms regulating DNA repair processes remain incompletely defined. Here, the circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as a tumor specific regulator of DNA repair. Key findings demonstrate that CRY1 expression is androgen-responsive and associates with poor outcome in prostate cancer. Functional studies and first-in-field mapping of the CRY1 cistrome and transcriptome reveal that CRY1 regulates DNA repair and the G2/M transition. DNA damage stabilizes CRY1 in cancer (in vitro, in vivo, and human tumors ex vivo), which proves critical for efficient DNA repair. Further mechanistic investigation shows that stabilized CRY1 temporally regulates expression of genes required for homologous recombination. Collectively, these findings reveal that CRY1 is hormone-induced in tumors, is further stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation. These studies identify the circadian factor CRY1 as pro-tumorigenic and nominate CRY1 as a new therapeutic target. |
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| DOI: | doi:10.1038/s41467-020-20513-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-020-20513-5 |
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| | Volltext: https://www.nature.com/articles/s41467-020-20513-5 |
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| | DOI: https://doi.org/10.1038/s41467-020-20513-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1750249316 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair / Shafi, Ayesha [VerfasserIn]; 15 January 2021 (Online-Ressource)
