Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-κB signaling pathways

• Verfasst von: Li-Weber, Min [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-κB signaling pathways
• Verf.angabe: Min Li-Weber, Monika K. Treiber, Marco Giaisi, Katalin Palfi, Nadja Stephan, Simone Parg,and Peter H. Krammer
• E-Jahr: 2005
• Jahr: August 15, 2005
• Umfang: 12 S.
• Teil: volume:175
• Teil: year:2005
• Teil: number:4
• Teil: pages:2132-2143
• Teil: extent:12
• Fussnoten: Gesehen am 04.03.2021
• Titel Quelle: Enthalten in: The journal of immunology
• Ort Quelle: Bethesda, Md. : Soc., 1916
• Jahr Quelle: 2005
• Band/Heft Quelle: 175(2005), 4, Seite 2132-2143
• ISSN Quelle: 1550-6606
• DOI: doi:10.4049/jimmunol.175.4.2132
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1750392739

Abstract

UV irradiation is carcinogenic and immunosuppressive. Previous studies indicate that UV-mediated alteration of APCs and induction of suppressor T cells play a critical role in UV-induced immune suppression. In this study, we show that UV irradiation can directly (independently of APCs and suppressor T cells) inhibit T cell activation by blocking TCR-mediated phosphorylation of ERK and IκB via overactivation of the p38 and JNK pathways. These events lead to the down-modulation of c-Jun, c-Fos, Egr-1, and NF-κB transcription factors and thereby inhibit production of cytokines, e.g., IL-2, IL-4, IFN-γ, and TNF-α, upon TCR stimulation. We also show that UV irradiation can suppress preactivated T cells, indicating that UV irradiation does not only impair T cell function in response to T cell activation, but can also have systemic effects that influence ongoing immune responses. Thus, our data provide an additional mechanism by which UV irradiation directly suppresses immune responses.