Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells

• Verfasst von: Herzer, Kerstin [VerfasserIn]
• Verfasst von: Ganten, Tom M. [VerfasserIn]
• Verfasst von: Schulze-Bergkamen, Henning [VerfasserIn]
• Verfasst von: Koschny, Ronald [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Verfasst von: Walczak, Henning [VerfasserIn]
• Titel: Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
• Verf.angabe: Kerstin Herzer, Tom M. Ganten, Henning Schulze‐Bergkamen, Anne Grosse‐Wilde, Ronald Koschny, Peter H. Krammer, and Henning Walczak
• E-Jahr: 2005
• Jahr: 16 June 2005
• Umfang: 10 S.
• Teil: volume:42
• Teil: year:2005
• Teil: number:1
• Teil: pages:183-192
• Teil: extent:10
• Fussnoten: Gesehen am 04.03.2021
• Titel Quelle: Enthalten in: Hepatology
• Ort Quelle: New York [u.a.] : Wiley Interscience, 1981
• Jahr Quelle: 2005
• Band/Heft Quelle: 42(2005), 1, Seite 183-192
• ISSN Quelle: 1527-3350
• DOI: doi:10.1002/hep.20757
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1750401622

Abstract

Transforming growth factor β (TGF-β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF-β-induced apoptosis and identified the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a mediator of TGF-β-induced apoptosis in hepatoma cells. TGF-β-induced apoptosis is significantly impaired upon blockage of TRAIL. We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF-β, whereas TRAIL receptor levels remain unchanged. In conclusion, our results provide evidence that the TRAIL system is critically involved in TGF-β-induced cell death in liver pathology.