| |  Online-Ressource |
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| Verfasst von: | Schmitz, Ingo [VerfasserIn]  |
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| | Weyd, Heiko [VerfasserIn] |
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| | Krueger, Andreas [VerfasserIn] |
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| | Baumann, Sven [VerfasserIn] |
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| | Fas, Stefanie C. [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Kirchhoff, Sabine [VerfasserIn] |
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| Titel: | Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort |
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| Verf.angabe: | Ingo Schmitz, Heiko Weyd, Andreas Krueger, Sven Baumann, Stefanie C. Fas, Peter H. Krammer, and Sabine Kirchhoff |
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| E-Jahr: | 2004 |
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| Jahr: | 5 February 2004 |
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| Umfang: | 7 S. |
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| Teil: | volume:172 |
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| | year:2004 |
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| | number:4 |
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| | day:15 |
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| | month:02 |
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| | pages:2194-2200 |
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| | extent:7 |
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| Fussnoten: | Im Titel ist "short" bei c-FLIP tiefgestellt ; Gesehen am 04.03.2021 |
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| Titel Quelle: | Enthalten in: The journal of immunology |
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| Ort Quelle: | Bethesda, Md. : Soc., 1916 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 172(2004), 4 vom: 15. Feb., Seite 2194-2200 |
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| ISSN Quelle: | 1550-6606 |
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| Abstract: | In the early phase of an immune response, T cells are activated and acquire effector functions. Whereas these short term activated T cells are resistant to CD95-mediated apoptosis, activated T cells in prolonged culture are readily sensitive, leading to activation-induced cell death and termination of the immune response. The translation inhibitor, cycloheximide, partially overcomes the apoptosis resistance of short term activated primary human T cells. Using this model we show in this study that sensitization of T cells to apoptosis occurs upstream of mitochondria. Neither death-inducing signaling complex formation nor expression of Bcl-2 proteins is altered in sensitized T cells. Although the caspase-8 inhibitor c-FLIPlong was only slightly down-regulated in sensitized T cells, c-FLIPshort became almost undetectable. This correlated with caspase-8 activation and apoptosis. These data suggest that c-FLIPshort, rather than c-FLIPlong, confers resistance of T cells to CD95-mediated apoptosis in the context of immune responses. |
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| DOI: | doi:10.4049/jimmunol.172.4.2194 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.4049/jimmunol.172.4.2194 |
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| | Volltext: https://www.jimmunol.org/content/172/4/2194 |
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| | DOI: https://doi.org/10.4049/jimmunol.172.4.2194 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1750442833 |
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| Verknüpfungen: | → Zeitschrift |
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Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort / Schmitz, Ingo [VerfasserIn]; 5 February 2004 (Online-Ressource)
