| Online-Ressource |
Verfasst von: | Schmitz, Ingo [VerfasserIn]  |
| Weyd, Heiko [VerfasserIn]  |
| Krueger, Andreas [VerfasserIn]  |
| Baumann, Sven [VerfasserIn]  |
| Fas, Stefanie C. [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
| Kirchhoff, Sabine [VerfasserIn]  |
Titel: | Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort |
Verf.angabe: | Ingo Schmitz, Heiko Weyd, Andreas Krueger, Sven Baumann, Stefanie C. Fas, Peter H. Krammer, and Sabine Kirchhoff |
E-Jahr: | 2004 |
Jahr: | 5 February 2004 |
Umfang: | 7 S. |
Teil: | volume:172 |
| year:2004 |
| number:4 |
| day:15 |
| month:02 |
| pages:2194-2200 |
| extent:7 |
Fussnoten: | Im Titel ist "short" bei c-FLIP tiefgestellt ; Gesehen am 04.03.2021 |
Titel Quelle: | Enthalten in: The journal of immunology |
Ort Quelle: | Bethesda, Md. : Soc., 1916 |
Jahr Quelle: | 2004 |
Band/Heft Quelle: | 172(2004), 4 vom: 15. Feb., Seite 2194-2200 |
ISSN Quelle: | 1550-6606 |
Abstract: | In the early phase of an immune response, T cells are activated and acquire effector functions. Whereas these short term activated T cells are resistant to CD95-mediated apoptosis, activated T cells in prolonged culture are readily sensitive, leading to activation-induced cell death and termination of the immune response. The translation inhibitor, cycloheximide, partially overcomes the apoptosis resistance of short term activated primary human T cells. Using this model we show in this study that sensitization of T cells to apoptosis occurs upstream of mitochondria. Neither death-inducing signaling complex formation nor expression of Bcl-2 proteins is altered in sensitized T cells. Although the caspase-8 inhibitor c-FLIPlong was only slightly down-regulated in sensitized T cells, c-FLIPshort became almost undetectable. This correlated with caspase-8 activation and apoptosis. These data suggest that c-FLIPshort, rather than c-FLIPlong, confers resistance of T cells to CD95-mediated apoptosis in the context of immune responses. |
DOI: | doi:10.4049/jimmunol.172.4.2194 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.4049/jimmunol.172.4.2194 |
| Volltext: https://www.jimmunol.org/content/172/4/2194 |
| DOI: https://doi.org/10.4049/jimmunol.172.4.2194 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1750442833 |
Verknüpfungen: | → Zeitschrift |
Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort / Schmitz, Ingo [VerfasserIn]; 5 February 2004 (Online-Ressource)