Pain hypersensitivity mechanisms at a glance

• Verfasst von: Gangadharan, Vijayan [VerfasserIn]
• Verfasst von: Kuner, Rohini [VerfasserIn]
• Titel: Pain hypersensitivity mechanisms at a glance
• Verf.angabe: Vijayan Gangadharan and Rohini Kuner
• E-Jahr: 2013
• Jahr: July 4, 2013
• Umfang: 7 S.
• Teil: volume:6
• Teil: year:2013
• Teil: number:4
• Teil: pages:889-895
• Teil: extent:7
• Fussnoten: Gesehen am 04.03.2021
• Titel Quelle: Enthalten in: Disease models & mechanisms
• Ort Quelle: Cambridge : Company of Biologists Limited, 2008
• Jahr Quelle: 2013
• Band/Heft Quelle: 6(2013), 4, Seite 889-895
• ISSN Quelle: 1754-8411
• DOI: doi:10.1242/dmm.011502
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1750447827

Abstract

Skip to Next Section - There are two basic categories of pain: physiological pain, which serves an important protective function, and pathological pain, which can have a major negative impact on quality of life in the context of human disease. Major progress has been made in understanding the molecular mechanisms that drive sensory transduction, amplification and conduction in peripheral pain-sensing neurons, communication of sensory inputs to spinal second-order neurons, and the eventual modulation of sensory signals by spinal and descending circuits. This poster article endeavors to provide an overview of how molecular and cellular mechanisms underlying nociception in a physiological context undergo plasticity in pathophysiological states, leading to pain hypersensitivity and chronic pain.