| |  Online-Ressource |
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| Verfasst von: | Wiedmann, Felix Tobias [VerfasserIn]  |
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| | Rinné, Susanne [VerfasserIn] |
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| | Donner, Birgit [VerfasserIn] |
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| | Decher, Niels [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Schmidt, Constanze [VerfasserIn] |
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| Titel: | Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system |
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| Verf.angabe: | Felix Wiedmann, Susanne Rinné, Birgit Donner, Niels Decher, Hugo A. Katus, Constanze Schmidt |
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| Jahr: | 2021 |
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| Jahr des Originals: | 2020 |
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| Umfang: | 10 S. |
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| Teil: | volume:159 |
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| | year:2021 |
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| | pages:126-135 |
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| | extent:10 |
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| Fussnoten: | Im Titel ist 2P tiefgestellt ; Available online 15 June 2020 ; Gesehen am 05.03.2021 |
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| Titel Quelle: | Enthalten in: Progress in biophysics & molecular biology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1963 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 159(2021), Seite 126-135 |
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| ISSN Quelle: | 1873-1732 |
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| Abstract: | TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K2P) channels mediate background potassium currents and regulate cellular excitability in many different types of cells. Their functional activity is controlled by a broad variety of different physiological stimuli, such as temperature, extracellular or intracellular pH, lipids and mechanical stress. By linking cellular excitability to mechanical stress, TREK-1 currents might be important to mediate parts of the mechanoelectrical feedback described in the heart. Furthermore, TREK-1 currents might contribute to the dysregulation of excitability in the heart in pathophysiological situations, such as those caused by abnormal stretch or ischaemia-associated cell swelling, thereby contributing to arrhythmogenesis. In this review, we focus on the functional role of TREK-1 in the heart and its putative contribution to cardiac mechanoelectrical coupling. Its cardiac expression among different species is discussed, alongside with functional evidence for TREK-1 currents in cardiomyocytes. In addition, evidence for the involvement of TREK-1 currents in different cardiac arrhythmias, such as atrial fibrillation or ventricular tachycardia, is summarized. Furthermore, the role of TREK-1 and its interaction partners in the regulation of the cardiac heart rate is reviewed. Finally, we focus on the significance of TREK-1 in the development of cardiac hypertrophy, cardiac fibrosis and heart failure. |
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| DOI: | doi:10.1016/j.pbiomolbio.2020.05.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.pbiomolbio.2020.05.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0079610720300432 |
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| | DOI: https://doi.org/10.1016/j.pbiomolbio.2020.05.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Arrhythmia |
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| | K2.1 |
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| | Mechanoelectrical feedback |
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| | MEF |
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| | TREK-1 |
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| K10plus-PPN: | 1750532557 |
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| Verknüpfungen: | → Zeitschrift |
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Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system / Wiedmann, Felix Tobias [VerfasserIn]; 2021 (Online-Ressource)
