Status: Bibliographieeintrag
Standort: ---
Exemplare:
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Verfasst von: | Leo, Albrecht [VerfasserIn]  |
| Kreft, Heidi [VerfasserIn]  |
| Hack, Hildegard [VerfasserIn]  |
| Roelcke, Dieter [VerfasserIn]  |
Titel: | Effect of low ionic strength on anti-Pr reactions |
Verf.angabe: | A. Leo, H. Kreft, H. Hack, D. Roelcke |
Jahr: | 1996 |
Umfang: | 4 S. |
Teil: | volume:33 |
| year:1996 |
| pages:22-25 |
| extent:4 |
Titel Quelle: | Enthalten in: Beiträge zur Infusionstherapie und Transfusionsmedizin |
Ort Quelle: | Basel [u.a.] : Karger, 1994 |
Jahr Quelle: | 1996 |
Band/Heft Quelle: | 33(1996), Seite 22-25 |
Abstract: | The effect of low ionic strength (LIS) on 28 anti-Pr, 20 anti-I and 20 anti-i cold agglutinins was investigated. The reaction of the anti-Pr CAs varies markedly. In most cases LIS has an enhancing effect. In some cases the thermal amplitude was widened so far that the reaction at 37 degrees C under LIS was stronger than at 0 degree C in PBS. With regard to the anti-Pr subspecificities anti Pr1, -Pr2 and -Pr3 or to the distinction of the immunodominant NeuNAc group (alpha a2,6- or alpha 2,3-bond) a correlation between these characteristics and the reaction in LIS could not be identified. The anti-I are not influenced by LISS, anti-i in a few cases. The reason for the variable reaction of the anti-Pr remains unclear. To further elucidate the LISS effect on anti-Pr, the contribution of the antibody structure should be regarded, but data for the use of H- and L-chain genes in anti-Pr are sparse. For compatibility testing in the routine laboratory, LISS-sensitive anti-Pr may play a role in disturbing the screening for RBC antibodies. |
Sprache: | eng |
Sach-SW: | Agglutinins |
| Antigen-Antibody Reactions |
| Blood Group Antigens |
| Cryoglobulins |
| Humans |
| Isoantigens |
| Osmolar Concentration |
| Temperature |
K10plus-PPN: | 1750536889 |
Verknüpfungen: | → Sammelwerk |
Effect of low ionic strength on anti-Pr reactions / Leo, Albrecht [VerfasserIn]; 1996
68707490