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Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag
Standort: ---
Exemplare: ---
heiBIB
Verfasst von:Leo, Albrecht [VerfasserIn]   i
 Kreft, Heidi [VerfasserIn]   i
 Hack, Hildegard [VerfasserIn]   i
 Roelcke, Dieter [VerfasserIn]   i
Titel:Effect of low ionic strength on anti-Pr reactions
Verf.angabe:A. Leo, H. Kreft, H. Hack, D. Roelcke
Jahr:1996
Umfang:4 S.
Teil:volume:33
 year:1996
 pages:22-25
 extent:4
Titel Quelle:Enthalten in: Beiträge zur Infusionstherapie und Transfusionsmedizin
Ort Quelle:Basel [u.a.] : Karger, 1994
Jahr Quelle:1996
Band/Heft Quelle:33(1996), Seite 22-25
Abstract:The effect of low ionic strength (LIS) on 28 anti-Pr, 20 anti-I and 20 anti-i cold agglutinins was investigated. The reaction of the anti-Pr CAs varies markedly. In most cases LIS has an enhancing effect. In some cases the thermal amplitude was widened so far that the reaction at 37 degrees C under LIS was stronger than at 0 degree C in PBS. With regard to the anti-Pr subspecificities anti Pr1, -Pr2 and -Pr3 or to the distinction of the immunodominant NeuNAc group (alpha a2,6- or alpha 2,3-bond) a correlation between these characteristics and the reaction in LIS could not be identified. The anti-I are not influenced by LISS, anti-i in a few cases. The reason for the variable reaction of the anti-Pr remains unclear. To further elucidate the LISS effect on anti-Pr, the contribution of the antibody structure should be regarded, but data for the use of H- and L-chain genes in anti-Pr are sparse. For compatibility testing in the routine laboratory, LISS-sensitive anti-Pr may play a role in disturbing the screening for RBC antibodies.
Sprache:eng
Sach-SW:Agglutinins
 Antigen-Antibody Reactions
 Blood Group Antigens
 Cryoglobulins
 Humans
 Isoantigens
 Osmolar Concentration
 Temperature
K10plus-PPN:1750536889
Verknüpfungen:→ Sammelwerk

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