Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Verfasst von: | Leo, Albrecht [VerfasserIn]  |
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| | Cartron, J. P. [VerfasserIn] |
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| | Strittmatter, M. [VerfasserIn] |
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| | Rowe, G. [VerfasserIn] |
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| | Roelcke, Dieter [VerfasserIn] |
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| Titel: | Case report |
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| Titelzusatz: | anti-Coa in a Co-(a+)-typed patient with chronic renal insufficiency |
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| Verf.angabe: | A. Leo, J.P. Cartron, M. Strittmatter, G. Rowe, D. Roelcke |
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| Jahr: | 1997 |
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| Umfang: | 5 S. |
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| Teil: | volume:34 |
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| | year:1997 |
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| | pages:185-189 |
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| | extent:5 |
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| Titel Quelle: | Enthalten in: Beiträge zur Infusionstherapie und Transfusionsmedizin |
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| Ort Quelle: | Basel [u.a.] : Karger, 1994 |
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| Jahr Quelle: | 1997 |
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| Band/Heft Quelle: | 34(1997), Seite 185-189 |
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| Abstract: | The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane and in the proximal tubule of the nephron. We identified a patient with the unique constellation of an antibody with the specificity anti-Coa and the Co (a+) phenotype. The serological antigen typing was confirmed by molecular typing with PCR-RFLP. The antibody has to be interpreted as an antibody against a partial Colton a antigen or as an autoantibody despite a negative direct antiglobulin test (DAT). The patient is suffering from chronic renal insufficiency of unknown origin, rising speculation about a pathophysiological relationship between the serological constellation and the clinical disease under the aspect of localization of the Colton antigens on AQP1. |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aquaporin 1 |
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| | Aquaporins |
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| | Blood Group Antigens |
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| | Blood Grouping and Crossmatching |
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| | Humans |
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| | Ion Channels |
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| | Isoantibodies |
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| | Kidney Failure, Chronic |
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| | Male |
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| | Phenotype |
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| | Renal Dialysis |
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| K10plus-PPN: | 1750539896 |
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| Verknüpfungen: | → Sammelwerk |
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Case report / Leo, Albrecht [VerfasserIn]; 1997
68707494
