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Verfasst von:Gangadharan, Vijayan [VerfasserIn]   i
 Selvaraj, Deepitha [VerfasserIn]   i
 Kurejova, Martina [VerfasserIn]   i
 Njoo, Christian [VerfasserIn]   i
 Gritsch, Simon [VerfasserIn]   i
 Škoricová, Dagmar [VerfasserIn]   i
 Horstmann, Heinz [VerfasserIn]   i
 Offermanns, Stefan [VerfasserIn]   i
 Brown, Andrew J. [VerfasserIn]   i
 Kuner, Thomas [VerfasserIn]   i
 Tappe-Theodor, Anke [VerfasserIn]   i
 Kuner, Rohini [VerfasserIn]   i
Titel:A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo
Verf.angabe:Vijayan Gangadharan, Deepitha Selvaraj, Martina Kurejova, Christian Njoo, Simon Gritsch, Dagmar Škoricová, Heinz Horstmann, Stefan Offermanns, Andrew J. Brown, Thomas Kuner, Anke Tappe-Theodor, Rohini Kuner
Jahr:2013
Umfang:12 S.
Teil:volume:154
 year:2013
 number:12
 pages:2801-2812
 extent:12
Fussnoten:Gesehen am 05.03.2021
Titel Quelle:Enthalten in: Pain
Ort Quelle:New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975
Jahr Quelle:2013
Band/Heft Quelle:154(2013), 12, Seite 2801-2812
ISSN Quelle:1872-6623
Abstract:Summary - Lysophosphatidylinositol (LPI) is a novel regulator of peripheral sensory neuron function and pathological pain. The roles of GPCR and non-GPCR components to the biological function of LPI are delineated. - The rich diversity of lipids and the specific signalling pathways they recruit provides tremendous scope for modulation of biological functions. Lysophosphatidylinositol (LPI) is emerging as a key modulator of cell proliferation, migration, and function, and holds important pathophysiological implications due to its high levels in diseased tissues, such as in cancer. Here we report a novel role for LPI in sensitization of peripheral sensory neurons, which was evident as exaggerated sensitivity to painful and innocuous pressure. Histopathological analyses indicated lack of involvement of myelin pathology and immune cell recruitment by LPI. Using pharmacological and conditional genetic tools in mice, we delineated receptor-mediated from non-receptor-mediated effects of LPI and we observed that GPR55, which functions as an LPI receptor when heterologously expressed in mammalian cells, only partially mediates LPI-induced actions in the context of pain sensitization in vivo; we demonstrate that, in vivo, LPI functions by activating Gα13 as well as Gαq/11 arms of G-protein signalling in sensory neurons. This study thus reports a novel pathophysiological function for LPI and elucidates underlying molecular mechanisms.
DOI:doi:10.1016/j.pain.2013.08.019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.pain.2013.08.019
 Volltext: https://journals.lww.com/pain/Fulltext/2013/12000/A_novel_biological_role_for_the_phospholipid.32.aspx
 DOI: https://doi.org/10.1016/j.pain.2013.08.019
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1750558068
Verknüpfungen:→ Zeitschrift

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