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| Verfasst von: | Costa, Barbara [VerfasserIn]  |
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| | Fletcher, Michael N. C. [VerfasserIn] |
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| | Boskovic, Pavle [VerfasserIn] |
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| | Ivanova, Ekaterina L. [VerfasserIn] |
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| | Eisemann, Tanja [VerfasserIn] |
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| | Lohr, Sabrina [VerfasserIn] |
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| | Bunse, Lukas [VerfasserIn] |
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| | Löwer, Martin [VerfasserIn] |
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| | Burchard, Stefanie [VerfasserIn] |
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| | Korshunov, Andrey [VerfasserIn] |
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| | Coltella, Nadia [VerfasserIn] |
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| | Cusimano, Melania [VerfasserIn] |
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| | Naldini, Luigi [VerfasserIn] |
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| | Liu, Hai-Kun [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Radlwimmer, Bernhard [VerfasserIn] |
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| | Angel, Peter [VerfasserIn] |
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| | Peterziel, Heike [VerfasserIn] |
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| Titel: | A set of cell lines derived from a genetic murine glioblastoma model recapitulates molecular and morphological characteristics of human tumors |
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| Verf.angabe: | Barbara Costa, Michael N.C. Fletcher, Pavle Boskovic, Ekaterina L. Ivanova, Tanja Eisemann, Sabrina Lohr, Lukas Bunse, Martin Löwer, Stefanie Burchard, Andrey Korshunov, Nadia Coltella, Melania Cusimano, Luigi Naldini, Hai-Kun Liu, Michael Platten, Bernhard Radlwimmer, Peter Angel and Heike Peterziel |
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| E-Jahr: | 2021 |
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| Jahr: | 10 January 2021 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 08.03.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 2, Artikel-ID 230, Seite 1-20 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Glioblastomas (GBM) are the most aggressive tumors affecting the central nervous system in adults, causing death within, on average, 15 months after diagnosis. Immunocompetent in-vivo models that closely mirror human GBM are urgently needed for deciphering glioma biology and for the development of effective treatment options. The murine GBM cell lines currently available for engraftment in immunocompetent mice are not only exiguous but also inadequate in representing prominent characteristics of human GBM such as infiltrative behavior, necrotic areas, and pronounced tumor heterogeneity. Therefore, we generated a set of glioblastoma cell lines by repeated in vivo passaging of cells isolated from a neural stem cell-specific Pten/p53 double-knockout genetic mouse brain tumor model. Transcriptome and genome analyses of the cell lines revealed molecular heterogeneity comparable to that observed in human glioblastoma. Upon orthotopic transplantation into syngeneic hosts, they formed high-grade gliomas that faithfully recapitulated the histopathological features, invasiveness and immune cell infiltration characteristic of human glioblastoma. These features make our cell lines unique and useful tools to study multiple aspects of glioblastoma pathomechanism and to test novel treatments in an intact immune microenvironment. |
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| DOI: | doi:10.3390/cancers13020230 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers13020230 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/2/230 |
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| | DOI: https://doi.org/10.3390/cancers13020230 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | glioblastoma |
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| | mouse model |
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| | syngeneic cell line |
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| K10plus-PPN: | 1750733676 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ set of cell lines derived from a genetic murine glioblastoma model recapitulates molecular and morphological characteristics of human tumors / Costa, Barbara [VerfasserIn]; 10 January 2021 (Online-Ressource)
