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Verfasst von:Nießen, Anna [VerfasserIn]   i
 Schimmack, Simon [VerfasserIn]   i
 Weber, Tim [VerfasserIn]   i
 Mayer, Philipp [VerfasserIn]   i
 Bergmann, Frank [VerfasserIn]   i
 Hinz, Ulf [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Strobel, Oliver [VerfasserIn]   i
Titel:Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas
Verf.angabe:Anna Nießen, Simon Schimmack, Tim F. Weber, Philipp Mayer, Frank Bergmann, Ulf Hinz, Markus W. Büchler, Oliver Strobel
Jahr:2021
Umfang:12 S.
Fussnoten:Available online 3 December 2020 ; Gesehen am 15.12.2021
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2021
Band/Heft Quelle:21(2021), 1, Seite 224-235
ISSN Quelle:1424-3911
Abstract:Background/objectives - Mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) of the pancreas and periampullary region are extremely rare and heterogeneous malignancies. Literature is sparse, clinical management is not standardized and little is known about survival outcomes. The aim of this study was to identify pathological and radiological features of MiNEN and assess the outcome of surgical management. - Methods - Patients undergoing surgery for pancreatic and periampullary MiNEN between 2001 and 2019 were retrospectively analysed based on a prospective database. Histological, radiological and clinical features were assessed. Survival was analysed in a nested case-control study and matched-pair analyses with pure neuroendocrine neoplasms (pNEN) and ductal adeno- or acinar cell carcinomas of the pancreas. A literature review with focus on survival after surgical resection was additionally performed. - Results - Of 13 patients with MiNEN, 5 had acinar-MiNEN and 8 adeno-MiNEN. Two of 5 (40%) acinar-MiNEN and one adeno-MiNEN patients had liver metastases. All but one adeno-MiNEN (88%) showed preoperative radiological features of pancreatic adenocarcinoma, 3 of 5 (60%) acinar-MiNEN exhibited mainly neuroendocrine features. No surgical mortality was observed. The 5-year overall survival rate in all MiNEN was 40%. Five-year survival rate was 58% in adeno-MiNEN and comparable to that of matched ductal adenocarcinomas (36%) and pNEN (48%). Five-year overall survival rate was 20% in acinar-MiNEN, compared to 39% in acinar carcinoma patients and 59% in matched pNEN patients. - Conclusions - MiNEN are rare and difficult to distinguish from pure adenocarcinoma or neuroendocrine neoplasm preoperatively. Surgical resection would therefore be the treatment of choice in localized tumors.
DOI:doi:10.1016/j.pan.2020.11.020
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.pan.2020.11.020
 Volltext: https://www.sciencedirect.com/science/article/pii/S142439032030853X
 DOI: https://doi.org/10.1016/j.pan.2020.11.020
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:MANEC
 MiNEN
 Mixed neuroendocrine non-neuroendocrine tumors
 Pancreatic neoplasm
K10plus-PPN:1750800799
Verknüpfungen:→ Zeitschrift

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