C332C genotype of glyoxalase 1 and its association with late diabetic complications

• Verfasst von: Gröner, Jan [VerfasserIn]
• Verfasst von: Reismann, Peter [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Kalscheuer, Hannes [VerfasserIn]
• Verfasst von: Lehnhoff, Daniel [VerfasserIn]
• Verfasst von: Hamann, Andreas [VerfasserIn]
• Verfasst von: Roser, Pia [VerfasserIn]
• Verfasst von: Bierhaus, Angelika [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Rudofsky, Gottfried [VerfasserIn]
• Titel: C332C genotype of glyoxalase 1 and its association with late diabetic complications
• Titelzusatz: Glo1 genotype and diabetic neuropathy
• Verf.angabe: J.B. Groener, P. Reismann, T. Fleming, H. Kalscheuer, D. Lehnhoff, A. Hamann, P. Roser, A. Bierhaus, P.P. Nawroth, G. Rudofsky
• E-Jahr: 2013
• Jahr: 17. Juni 2013
• Umfang: 4 S.
• Teil: volume:121
• Teil: year:2013
• Teil: number:7
• Teil: pages:436-439
• Teil: extent:4
• Fussnoten: Gesehen am 10.03.2021
• Titel Quelle: Enthalten in: Experimental and clinical endocrinology & diabetes
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1983
• Jahr Quelle: 2013
• Band/Heft Quelle: 121(2013), 7, Seite 436-439
• ISSN Quelle: 1439-3646
• ISSN Quelle: 2976-2073
• DOI: doi:10.1055/s-0033-1345124
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1750922347

Abstract

<p>Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes. Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes.</p> <p>Genotyping was performed in 209 patients with type 1 and 524 patients with type 2 diabetes using polymerase chain reaction and subsequent cleavage by restriction endonuclease Bsa I.</p> <p>Frequencies of the glyoxalase 1 genotypes were different with respect to diabetes type with a significantly higher prevalence of A332A-genotype in type 1 diabetes (35.9% vs. 27.3%; p=0.03). In type 1 diabetes, there was no correlation of any genotype with diabetic retinopathy, nephropathy or neuropathy. In contrast, type 2 diabetic patients homozygous for the C332C allele showed a significantly increased prevalence of diabetic neuropathy (p=0.03; OR=1.49 [95%-CI: 1.04; 2.11]), while no association with diabetic nephropathy or retinopathy was found. However, the significance of this association was lost after correction for multiple testing.</p> <p>Our data suggest a possible association of C332C-genotype of the glyoxalase 1 gene with diabetic neuropathy in type 2 diabetes, supporting the hypothesis that methylglyoxal might be an important mediator of diabetic neuropathy in type 2 diabetes.</p>