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Verfasst von:Grond-Ginsbach, Caspar [VerfasserIn]   i
 Giossi, A. [VerfasserIn]   i
 Aksay, Suna Su [VerfasserIn]   i
 Engelter, S. T. [VerfasserIn]   i
 Lyrer, P. A. [VerfasserIn]   i
 Metso, T. M. [VerfasserIn]   i
 Metso, A. J. [VerfasserIn]   i
 Tatlisumak, T. [VerfasserIn]   i
 Debette, S. [VerfasserIn]   i
 Leys, D. [VerfasserIn]   i
 Thijs, V. [VerfasserIn]   i
 Bersano, A. [VerfasserIn]   i
 Abboud, S. [VerfasserIn]   i
 Kloss, Manja [VerfasserIn]   i
 Lichy, Christoph [VerfasserIn]   i
 Grau, Armin J. [VerfasserIn]   i
 Pezzini, Alessandro [VerfasserIn]   i
 Touzé, E. [VerfasserIn]   i
Titel:Elevated peripheral leukocyte counts in acute cervical artery dissection
Verf.angabe:C. Grond‐Ginsbach, A. Giossi, S.S. Aksay, S.T. Engelter, P.A. Lyrer, T.M. Metso, A.J. Metso, T. Tatlisumak, S. Debette, D. Leys, V. Thijs, A. Bersano, S. Abboud, M. Kloss, C. Lichy, A. Grau, A. Pezzini and E. Touzé for the CADISP group
E-Jahr:2013
Jahr:12 June 2013
Umfang:6 S.
Teil:volume:20
 year:2013
 number:10
 pages:1405-1410
 extent:6
Fussnoten:Gesehen am 11.03.2021
Titel Quelle:Enthalten in: European journal of neurology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1994
Jahr Quelle:2013
Band/Heft Quelle:20(2013), 10, Seite 1405-1410
ISSN Quelle:1468-1331
Abstract:Background and purpose It has been suggested that inflammation may play a role in the development of cervical artery dissection (CeAD), but evidence remains scarce. Methods A total of 172 patients were included with acute (< 24 h) CeAD and 348 patients with acute ischaemic stroke (IS) of other (non-CeAD) causes from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study, and 223 age- and sex-matched healthy control subjects. White blood cell (WBC) counts collected at admission were compared across the three groups. Results Compared with healthy control subjects, CeAD patients and non-CeAD stroke patients had higher WBC counts (P < 0.001). Patients with CeAD had higher WBC counts and were more likely to have WBC > 10 000/μl than non-CeAD stroke patients (38.4% vs. 23.0%, P < 0.001) and healthy controls (38.4% vs. 8.5%, P < 0.001). WBC counts were higher in CeAD (9.4 ± 3.3) than in IS of other causes (large artery atherosclerosis, 8.7 ± 2.3; cardioembolism, 8.2 ± 2.8; small vessel disease, 8.4 ± 2.4; undetermined cause, 8.8 ± 3.1; P = 0.022). After adjustment for age, sex, stroke severity and vascular risk factors in a multiple regression model, elevated WBC count remained associated with CeAD, as compared with non-CeAD stroke patients [odds ratio (OR) = 2.56; 95% CI 1.60-4.11; P < 0.001) and healthy controls (OR = 6.27; 95% CI 3.39-11.61; P < 0.001). Conclusions Acute CeAD was associated with particularly high WBC counts. Leukocytosis may reflect a pre-existing inflammatory state, supporting the link between inflammation and CeAD.
DOI:doi:10.1111/ene.12201
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/https://doi.org/10.1111/ene.12201
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.12201
 DOI: https://doi.org/10.1111/ene.12201
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cervical artery dissection
 inflammation
 leukocytosis
 white blood cell count
K10plus-PPN:1751087344
Verknüpfungen:→ Zeitschrift

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