Elevated peripheral leukocyte counts in acute cervical artery dissection

• Verfasst von: Grond-Ginsbach, Caspar [VerfasserIn]
• Verfasst von: Giossi, A. [VerfasserIn]
• Verfasst von: Aksay, Suna Su [VerfasserIn]
• Verfasst von: Engelter, S. T. [VerfasserIn]
• Verfasst von: Lyrer, P. A. [VerfasserIn]
• Verfasst von: Metso, T. M. [VerfasserIn]
• Verfasst von: Metso, A. J. [VerfasserIn]
• Verfasst von: Tatlisumak, T. [VerfasserIn]
• Verfasst von: Debette, S. [VerfasserIn]
• Verfasst von: Leys, D. [VerfasserIn]
• Verfasst von: Thijs, V. [VerfasserIn]
• Verfasst von: Bersano, A. [VerfasserIn]
• Verfasst von: Abboud, S. [VerfasserIn]
• Verfasst von: Kloss, Manja [VerfasserIn]
• Verfasst von: Lichy, Christoph [VerfasserIn]
• Verfasst von: Grau, Armin J. [VerfasserIn]
• Verfasst von: Pezzini, Alessandro [VerfasserIn]
• Verfasst von: Touzé, E. [VerfasserIn]
• Titel: Elevated peripheral leukocyte counts in acute cervical artery dissection
• Verf.angabe: C. Grond‐Ginsbach, A. Giossi, S.S. Aksay, S.T. Engelter, P.A. Lyrer, T.M. Metso, A.J. Metso, T. Tatlisumak, S. Debette, D. Leys, V. Thijs, A. Bersano, S. Abboud, M. Kloss, C. Lichy, A. Grau, A. Pezzini and E. Touzé for the CADISP group
• E-Jahr: 2013
• Jahr: 12 June 2013
• Umfang: 6 S.
• Teil: volume:20
• Teil: year:2013
• Teil: number:10
• Teil: pages:1405-1410
• Teil: extent:6
• Fussnoten: Gesehen am 11.03.2021
• Titel Quelle: Enthalten in: European journal of neurology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1994
• Jahr Quelle: 2013
• Band/Heft Quelle: 20(2013), 10, Seite 1405-1410
• ISSN Quelle: 1468-1331
• DOI: doi:10.1111/ene.12201
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cervical artery dissection
• Sach-SW: inflammation
• Sach-SW: leukocytosis
• Sach-SW: white blood cell count
• K10plus-PPN: 1751087344

Abstract

Background and purpose It has been suggested that inflammation may play a role in the development of cervical artery dissection (CeAD), but evidence remains scarce. Methods A total of 172 patients were included with acute (< 24 h) CeAD and 348 patients with acute ischaemic stroke (IS) of other (non-CeAD) causes from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study, and 223 age- and sex-matched healthy control subjects. White blood cell (WBC) counts collected at admission were compared across the three groups. Results Compared with healthy control subjects, CeAD patients and non-CeAD stroke patients had higher WBC counts (P < 0.001). Patients with CeAD had higher WBC counts and were more likely to have WBC > 10 000/μl than non-CeAD stroke patients (38.4% vs. 23.0%, P < 0.001) and healthy controls (38.4% vs. 8.5%, P < 0.001). WBC counts were higher in CeAD (9.4 ± 3.3) than in IS of other causes (large artery atherosclerosis, 8.7 ± 2.3; cardioembolism, 8.2 ± 2.8; small vessel disease, 8.4 ± 2.4; undetermined cause, 8.8 ± 3.1; P = 0.022). After adjustment for age, sex, stroke severity and vascular risk factors in a multiple regression model, elevated WBC count remained associated with CeAD, as compared with non-CeAD stroke patients [odds ratio (OR) = 2.56; 95% CI 1.60-4.11; P < 0.001) and healthy controls (OR = 6.27; 95% CI 3.39-11.61; P < 0.001). Conclusions Acute CeAD was associated with particularly high WBC counts. Leukocytosis may reflect a pre-existing inflammatory state, supporting the link between inflammation and CeAD.