| |  Online-Ressource |
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| Verfasst von: | Kvacskay, Peter [VerfasserIn]  |
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| | Yao, Nina [VerfasserIn] |
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| | Schnotz, Jürgen-Heinz [VerfasserIn] |
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| | Scarpone, Roberta [VerfasserIn] |
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| | Carvalho, Rui de Albuquerque [VerfasserIn] |
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| | Klika, Karel D. [VerfasserIn] |
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| | Merkt, Wolfgang [VerfasserIn] |
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| | Tretter, Theresa [VerfasserIn] |
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| | Lorenz, Hanns-Martin [VerfasserIn] |
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| | Tykocinski, Lars-Oliver [VerfasserIn] |
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| Titel: | Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype |
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| Titelzusatz: | new targets for therapy? |
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| Verf.angabe: | Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz and Lars-Oliver Tykocinski |
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| E-Jahr: | 2021 |
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| Jahr: | 15 February 2021 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 30.11.2021 |
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| Titel Quelle: | Enthalten in: Arthritis Research & Therapy |
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| Ort Quelle: | London : BioMed Central, 1999 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 23(2021), Artikel-ID 56, Seite 1-15 |
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| ISSN Quelle: | 1465-9913 |
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| | 1478-6362 |
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| Abstract: | A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the metabolism of SF. Thus, this study investigates the effect of Th cells on the glucose metabolism and phenotype of SF and how this is influenced by the blockade of cytokines, janus kinases (JAKs) and glycolysis. |
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| DOI: | doi:10.1186/s13075-021-02437-7 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1186/s13075-021-02437-7 |
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| | DOI: https://doi.org/10.1186/s13075-021-02437-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Fibroblast-like synoviocytes |
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| | Glycolysis |
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| | Inflammation |
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| | Janus kinases |
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| | Metabolism |
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| | Rheumatoid arthritis |
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| | Synovial fibroblasts |
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| | T helper cells |
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| | T lymphocytes |
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| | Translational research |
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| K10plus-PPN: | 1751136914 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype / Kvacskay, Peter [VerfasserIn]; 15 February 2021 (Online-Ressource)
