Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Verdelho, Ana [VerfasserIn]   i
 Madureira, S. [VerfasserIn]   i
 Moleiro, C. [VerfasserIn]   i
 Ferro, J. M. [VerfasserIn]   i
 Santos, C. O. [VerfasserIn]   i
 Erkinjuntti, T. [VerfasserIn]   i
 Pantoni, L. [VerfasserIn]   i
 Fazekas, F. [VerfasserIn]   i
 Visser, M. [VerfasserIn]   i
 Waldemar, G. [VerfasserIn]   i
 Wallin, A. [VerfasserIn]   i
 Hennerici, Michael G. [VerfasserIn]   i
 Inzitari, D. [VerfasserIn]   i
Titel:White matter changes and diabetes predict cognitive decline in the elderly
Titelzusatz:The LADIS Study
Verf.angabe:A. Verdelho, S. Madureira, C. Moleiro, J. M. Ferro, C. O. Santos, T. Erkinjuntti, L. Pantoni, F. Fazekas, M. Visser, G. Waldemar, A. Wallin, M. Hennerici, D. Inzitari
E-Jahr:2010
Jahr:[2010]
Umfang:8 S.
Fussnoten:Gesehen am 12.03.2021
Titel Quelle:Enthalten in: Neurology
Ort Quelle:Philadelphia, Pa. : Wolters Kluwer, 1951
Jahr Quelle:2010
Band/Heft Quelle:75(2010), 2 vom: Juli, Seite 160-167
ISSN Quelle:1526-632X
Abstract:Objective: We aimed to study if age-related white matter changes (WMC) and vascular risk factors were predictors of cognitive decline in elderly subjects with WMC living independently. - Methods: The Leukoaraiosis and Disability prospective multinational European study (LADIS) evaluates the impact of WMC on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Additionally, dementia, subtypes of dementia, and cognitive decline without dementia were classified according to usual clinical criteria. MRI was performed at entry and at the end of the study. - Results: A total of 639 subjects were included (74.1 ± 5 years, 55% women, 9.6 ± 3.8 years of schooling). At end of follow-up, 90 patients had dementia and 147 had cognitive impairment no dementia. Using Cox regression analysis, WMC severity independently predicted cognitive decline (dementia and not dementia), independently of age, education, and medial temporal atrophy (MTA). Diabetes at baseline was the only vascular risk factor that independently predicted cognitive decline during follow-up, controlling for age, education, WMC severity, and temporal atrophy. Considering subtypes of dementia, Alzheimer disease (AD) was predicted only by MTA, while vascular dementia was predicted by previous stroke, WMC severity, and MTA. - Conclusion: WMC severity and diabetes are independent predictors of cognitive decline in an initially nondisabled elderly population. Vascular dementia is predicted by previous stroke and WMC, while AD is predicted only by MTA.
DOI:doi:10.1212/WNL.0b013e3181e7ca05
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1212/WNL.0b013e3181e7ca05
 Volltext: https://n.neurology.org/content/75/2/160
 DOI: https://doi.org/10.1212/WNL.0b013e3181e7ca05
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1751214494
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68712151   QR-Code
zum Seitenanfang