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Verfasst von:Heiland, Sabine [VerfasserIn]   i
 Benner, Thomas [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Rempp, Katrin [VerfasserIn]   i
 Reith, Wolfgang [VerfasserIn]   i
 Sartor, Klaus [VerfasserIn]   i
Titel:Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier
Verf.angabe:Sabine Heiland, Thomas Benner, Jürgen Debus, Katrin Rempp, Wolfgang Reith, and Klaus Sartor
E-Jahr:1999
Jahr:28 June 1999
Umfang:7 S.
Teil:volume:17
 year:1999
 number:1
 pages:21-27
 extent:7
Fussnoten:Gesehen am 15.03.2021
Titel Quelle:Enthalten in: Magnetic resonance imaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:1999
Band/Heft Quelle:17(1999), 1, Seite 21-27
ISSN Quelle:1873-5894
Abstract:The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we implemented a dual-echo RF-spoiled FLASH sequence (TE = 6/23.6 ms). We developed a postprocessing routine that allowed to calculate a signal-time course representing only the change in T2∗ and another one representing only the change in T1. Using this method, we examined 7 patients with various brain lesions showing evidence of BBB disruption. In the signal-time-curves obtained from the early echo we found a distinct signal drop due to the T2∗ effect. These effects could be eliminated by the correction algorithm yielding a 67% higher signal increase. Correction of the signal-time curve of the late echo yielded a more pronounced maximum signal drop and a decrease in postcontrast signal intensity. We found that without this correction the relative regional cerebral blood volume and the first moment of the concentration-time curve were underestimated by 72% and 22%, respectively. The dual echo-sequence combined with the postprocessing algorithm separates T1 and T2∗ effects and thus allows to assess cerebral hemodynamics and contrast agent kinetics simultaneously. This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors.
DOI:doi:10.1016/S0730-725X(98)00149-0
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S0730-725X(98)00149-0
 Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X98001490
 DOI: https://doi.org/10.1016/S0730-725X(98)00149-0
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Blood-brain-barrier
 Contrast media
 Perfusion MRI
 Permeability
K10plus-PPN:1751321436
Verknüpfungen:→ Zeitschrift

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