Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Heiland, Sabine [VerfasserIn]  |
| Benner, Thomas [VerfasserIn]  |
| Debus, Jürgen [VerfasserIn]  |
| Rempp, Katrin [VerfasserIn]  |
| Reith, Wolfgang [VerfasserIn]  |
| Sartor, Klaus [VerfasserIn]  |
Titel: | Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier |
Verf.angabe: | Sabine Heiland, Thomas Benner, Jürgen Debus, Katrin Rempp, Wolfgang Reith, and Klaus Sartor |
E-Jahr: | 1999 |
Jahr: | 28 June 1999 |
Umfang: | 7 S. |
Teil: | volume:17 |
| year:1999 |
| number:1 |
| pages:21-27 |
| extent:7 |
Fussnoten: | Gesehen am 15.03.2021 |
Titel Quelle: | Enthalten in: Magnetic resonance imaging |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1982 |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 17(1999), 1, Seite 21-27 |
ISSN Quelle: | 1873-5894 |
Abstract: | The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we implemented a dual-echo RF-spoiled FLASH sequence (TE = 6/23.6 ms). We developed a postprocessing routine that allowed to calculate a signal-time course representing only the change in T2∗ and another one representing only the change in T1. Using this method, we examined 7 patients with various brain lesions showing evidence of BBB disruption. In the signal-time-curves obtained from the early echo we found a distinct signal drop due to the T2∗ effect. These effects could be eliminated by the correction algorithm yielding a 67% higher signal increase. Correction of the signal-time curve of the late echo yielded a more pronounced maximum signal drop and a decrease in postcontrast signal intensity. We found that without this correction the relative regional cerebral blood volume and the first moment of the concentration-time curve were underestimated by 72% and 22%, respectively. The dual echo-sequence combined with the postprocessing algorithm separates T1 and T2∗ effects and thus allows to assess cerebral hemodynamics and contrast agent kinetics simultaneously. This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors. |
DOI: | doi:10.1016/S0730-725X(98)00149-0 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0730-725X(98)00149-0 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X98001490 |
| DOI: https://doi.org/10.1016/S0730-725X(98)00149-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Blood-brain-barrier |
| Contrast media |
| Perfusion MRI |
| Permeability |
K10plus-PPN: | 1751321436 |
Verknüpfungen: | → Zeitschrift |
Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier / Heiland, Sabine [VerfasserIn]; 28 June 1999 (Online-Ressource)
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