Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier

• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Benner, Thomas [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Rempp, Katrin [VerfasserIn]
• Verfasst von: Reith, Wolfgang [VerfasserIn]
• Verfasst von: Sartor, Klaus [VerfasserIn]
• Titel: Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier
• Verf.angabe: Sabine Heiland, Thomas Benner, Jürgen Debus, Katrin Rempp, Wolfgang Reith, and Klaus Sartor
• E-Jahr: 1999
• Jahr: 28 June 1999
• Umfang: 7 S.
• Teil: volume:17
• Teil: year:1999
• Teil: number:1
• Teil: pages:21-27
• Teil: extent:7
• Fussnoten: Gesehen am 15.03.2021
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 1999
• Band/Heft Quelle: 17(1999), 1, Seite 21-27
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/S0730-725X(98)00149-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Blood-brain-barrier
• Sach-SW: Contrast media
• Sach-SW: Perfusion MRI
• Sach-SW: Permeability
• K10plus-PPN: 1751321436

Abstract

The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we implemented a dual-echo RF-spoiled FLASH sequence (TE = 6/23.6 ms). We developed a postprocessing routine that allowed to calculate a signal-time course representing only the change in T2∗ and another one representing only the change in T1. Using this method, we examined 7 patients with various brain lesions showing evidence of BBB disruption. In the signal-time-curves obtained from the early echo we found a distinct signal drop due to the T2∗ effect. These effects could be eliminated by the correction algorithm yielding a 67% higher signal increase. Correction of the signal-time curve of the late echo yielded a more pronounced maximum signal drop and a decrease in postcontrast signal intensity. We found that without this correction the relative regional cerebral blood volume and the first moment of the concentration-time curve were underestimated by 72% and 22%, respectively. The dual echo-sequence combined with the postprocessing algorithm separates T1 and T2∗ effects and thus allows to assess cerebral hemodynamics and contrast agent kinetics simultaneously. This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors.