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Status: Bibliographieeintrag

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Verfasst von:González-González, Ana I. [VerfasserIn]   i
 Meid, Andreas [VerfasserIn]   i
 Haefeli, Walter E. [VerfasserIn]   i
Titel:A prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy
Verf.angabe:Ana I. González-González, Andreas D. Meid, Truc S. Dinh, Jeanet W. Blom, Marjan van den Akker, Petra J.M. Elders, Ulrich Thiem, Daniela Küllenberg De Gaudry, Karin M.A. Swart, Henrik Rudolf, Donna Bosch-Lenders, Hans-Joachim Trampisch, Joerg J. Meerpohl, Ferdinand M. Gerlach, Benno Flaig, Ghainsom Kom, Kym I.E. Snell, Rafael Perera, Walter E. Haefeli, Paul P. Glasziou, Christiane Muth
Jahr:2021
Jahr des Originals:2020
Umfang:12 S.
Fussnoten:Published online 13 October 2020 ; Gesehen am 12.05.2021
Titel Quelle:Enthalten in: Journal of clinical epidemiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1988
Jahr Quelle:2021
Band/Heft Quelle:130(2021), Seite 1-12
ISSN Quelle:1878-5921
Abstract:Objectives - To develop and validate a prognostic model to predict deterioration in health-related quality of life (dHRQoL) in older general practice patients with at least one chronic condition and one chronic prescription. - Study Design and Setting - We used individual participant data from five cluster-randomized trials conducted in the Netherlands and Germany to predict dHRQoL, defined as a decrease in EQ-5D-3 L index score of ≥5% after 6-month follow-up in logistic regression models with stratified intercepts to account for between-study heterogeneity. The model was validated internally and by using internal-external cross-validation (IECV). - Results - In 3,582 patients with complete data, of whom 1,046 (29.2%) showed deterioration in HRQoL, and 12/87 variables were selected that were related to single (chronic) conditions, inappropriate medication, medication underuse, functional status, well-being, and HRQoL. Bootstrap internal validation showed a C-statistic of 0.71 (0.69 to 0.72) and a calibration slope of 0.88 (0.78 to 0.98). In the IECV loop, the model provided a pooled C-statistic of 0.68 (0.65 to 0.70) and calibration-in-the-large of 0 (−0.13 to 0.13). HRQoL/functionality had the strongest prognostic value. - Conclusion - The model performed well in terms of discrimination, calibration, and generalizability and might help clinicians identify older patients at high risk of dHRQoL. - Registration - PROSPERO ID: CRD42018088129.
DOI:doi:10.1016/j.jclinepi.2020.10.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jclinepi.2020.10.006
 Volltext: https://www.sciencedirect.com/science/article/pii/S0895435620311458
 DOI: https://doi.org/10.1016/j.jclinepi.2020.10.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Elderly
 Functional status
 Multimorbidity
 Patient-centered care
 Polypharmacy
 Prognostic model
 Quality of life
K10plus-PPN:175132818X
Verknüpfungen:→ Zeitschrift

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