| Online-Ressource |
Verfasst von: | González-González, Ana I. [VerfasserIn]  |
| Meid, Andreas [VerfasserIn]  |
| Haefeli, Walter E. [VerfasserIn]  |
Titel: | A prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy |
Verf.angabe: | Ana I. González-González, Andreas D. Meid, Truc S. Dinh, Jeanet W. Blom, Marjan van den Akker, Petra J.M. Elders, Ulrich Thiem, Daniela Küllenberg De Gaudry, Karin M.A. Swart, Henrik Rudolf, Donna Bosch-Lenders, Hans-Joachim Trampisch, Joerg J. Meerpohl, Ferdinand M. Gerlach, Benno Flaig, Ghainsom Kom, Kym I.E. Snell, Rafael Perera, Walter E. Haefeli, Paul P. Glasziou, Christiane Muth |
Jahr: | 2021 |
Jahr des Originals: | 2020 |
Umfang: | 12 S. |
Fussnoten: | Published online 13 October 2020 ; Gesehen am 12.05.2021 |
Titel Quelle: | Enthalten in: Journal of clinical epidemiology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1988 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 130(2021), Seite 1-12 |
ISSN Quelle: | 1878-5921 |
Abstract: | Objectives - To develop and validate a prognostic model to predict deterioration in health-related quality of life (dHRQoL) in older general practice patients with at least one chronic condition and one chronic prescription. - Study Design and Setting - We used individual participant data from five cluster-randomized trials conducted in the Netherlands and Germany to predict dHRQoL, defined as a decrease in EQ-5D-3 L index score of ≥5% after 6-month follow-up in logistic regression models with stratified intercepts to account for between-study heterogeneity. The model was validated internally and by using internal-external cross-validation (IECV). - Results - In 3,582 patients with complete data, of whom 1,046 (29.2%) showed deterioration in HRQoL, and 12/87 variables were selected that were related to single (chronic) conditions, inappropriate medication, medication underuse, functional status, well-being, and HRQoL. Bootstrap internal validation showed a C-statistic of 0.71 (0.69 to 0.72) and a calibration slope of 0.88 (0.78 to 0.98). In the IECV loop, the model provided a pooled C-statistic of 0.68 (0.65 to 0.70) and calibration-in-the-large of 0 (−0.13 to 0.13). HRQoL/functionality had the strongest prognostic value. - Conclusion - The model performed well in terms of discrimination, calibration, and generalizability and might help clinicians identify older patients at high risk of dHRQoL. - Registration - PROSPERO ID: CRD42018088129. |
DOI: | doi:10.1016/j.jclinepi.2020.10.006 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jclinepi.2020.10.006 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0895435620311458 |
| DOI: https://doi.org/10.1016/j.jclinepi.2020.10.006 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Elderly |
| Functional status |
| Multimorbidity |
| Patient-centered care |
| Polypharmacy |
| Prognostic model |
| Quality of life |
K10plus-PPN: | 175132818X |
Verknüpfungen: | → Zeitschrift |
¬A¬ prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy / González-González, Ana I. [VerfasserIn]; 2021 (Online-Ressource)