Lung screening benefits and challenges

• Verfasst von: Sands, Jacob [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Stackelberg, Oyunbileg von [VerfasserIn]
• Titel: Lung screening benefits and challenges
• Titelzusatz: a review of the data and outline for implementation
• Verf.angabe: Jacob Sands, MD, Martin C. Tammemägi, PhD, Sebastien Couraud, MD, PhD, David R. Baldwin, MD, FRCP, Andrea Borondy-Kitts, MS, MPH, David Yankelevitz, MD, Jennifer Lewis, MD, Fred Grannis, MD, Hans-Ulrich Kauczor, MD, Oyunbileg von Stackelberg, PhD, Lecia Sequist, MD, Ugo Pastorino, MD, Brady McKee, MD
• Jahr: 2021
• Jahr des Originals: 2020
• Umfang: 17 S.
• Teil: volume:16
• Teil: year:2021
• Teil: number:1
• Teil: pages:37-53
• Teil: extent:17
• Fussnoten: Available online 12 November 2020 ; Gesehen am 12.05.2021
• Titel Quelle: Enthalten in: Journal of thoracic oncology
• Ort Quelle: Amsterdam : Elsevier, 2006
• Jahr Quelle: 2021
• Band/Heft Quelle: 16(2021), 1, Seite 37-53
• ISSN Quelle: 1556-1380
• DOI: doi:10.1016/j.jtho.2020.10.127
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CTLS
• Sach-SW: LDCT
• Sach-SW: low-dose CT
• Sach-SW: Lung cancer screening
• K10plus-PPN: 1751328856

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for almost a fifth of all cancer-related deaths. Annual computed tomographic lung cancer screening (CTLS) detects lung cancer at earlier stages and reduces lung cancer-related mortality among high-risk individuals. Many medical organizations, including the U.S. Preventive Services Task Force, recommend annual CTLS in high-risk populations. However, fewer than 5% of individuals worldwide at high risk for lung cancer have undergone screening. In large part, this is owing to delayed implementation of CTLS in many countries throughout the world. Factors contributing to low uptake in countries with longstanding CTLS endorsement, such as the United States, include lack of patient and clinician awareness of current recommendations in favor of CTLS and clinician concerns about CTLS-related radiation exposure, false-positive results, overdiagnosis, and cost. This review of the literature serves to address these concerns by evaluating the potential risks and benefits of CTLS. Review of key components of a lung screening program, along with an updated shared decision aid, provides guidance for program development and optimization. Review of studies evaluating the population considered “high-risk” is included as this may affect future guidelines within the United States and other countries considering lung screening implementation.