| |  Online-Ressource |
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| Verfasst von: | Zhang, Man [VerfasserIn]  |
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| | Sun, Qian [VerfasserIn] |
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| | Liu, Yiling [VerfasserIn] |
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| | Chu, Zhiqin [VerfasserIn] |
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| | Yu, Leixiao [VerfasserIn] |
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| | Hou, Yong [VerfasserIn] |
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| | Kang, Heemin [VerfasserIn] |
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| | Wei, Qiang [VerfasserIn] |
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| | Zhao, Weifeng [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| | Zhao, Changsheng [VerfasserIn] |
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| | Cavalcanti-Adam, Elisabetta A. [VerfasserIn] |
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| Titel: | Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels |
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| Verf.angabe: | Man Zhang, Qian Sun, Yiling Liu, Zhiqin Chu, Leixiao Yu, Yong Hou, Heemin Kang, Qiang Wei, Weifeng Zhao, Joachim P. Spatz, Changsheng Zhao, Elisabetta A. Cavalcanti-Adam |
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| Jahr: | 2021 |
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| Jahr des Originals: | 2020 |
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| Umfang: | 12 S. |
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| Fussnoten: | Available online 23 November 2020 ; Gesehen am 17.03.2021 |
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| Titel Quelle: | Enthalten in: Biomaterials |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 268(2021), Artikel-ID 120543, Seite 1-12 |
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| ISSN Quelle: | 0142-9612 |
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| Abstract: | Hydrogels with tunable mechanical properties have provided a tremendous opportunity to regulate stem cell differentiation. Hydrogels with osteoid (about 30-40 kPa) or higher stiffness are usually required to induce the osteogenic differentiation of mesenchymal stem cells (MSCs). It is yet difficult to achieve the same differentiation on very soft hydrogels, because of low environmental mechanical stimuli and restricted cellular mechanotransduction. Here, we modulate cellular spatial sensing of integrin-adhesive ligands via quasi-hexagonally arranged nanopatterns to promote cell mechanosensing on hydrogels having low stiffness (about 3 kPa). The increased interligand spacing has been shown to regulate actomyosin force loading to recruit extra integrins on soft hydrogels. It therefore activates mechanotransduction and promotes the osteogenic differentiation of MSCs on soft hydrogels to the level comparable with the one observed on osteoid stiffness. Our work opens up new possibilities for the design of biomaterials and tissue scaffolds for regenerative therapeutics. |
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| DOI: | doi:10.1016/j.biomaterials.2020.120543 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.biomaterials.2020.120543 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0142961220307894 |
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| | DOI: https://doi.org/10.1016/j.biomaterials.2020.120543 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Differentiation |
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| | Hydrogel |
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| | Ligand spacing |
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| | Mechanotransduction |
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| | Mesenchymal stem cell |
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| K10plus-PPN: | 175157427X |
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| Verknüpfungen: | → Zeitschrift |
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Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels / Zhang, Man [VerfasserIn]; 2021 (Online-Ressource)
