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| Verfasst von: | Blahak, Christian [VerfasserIn]  |
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| | Bäzner, Hansjörg [VerfasserIn] |
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| | Capelle, Hans-Holger [VerfasserIn] |
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| | Wöhrle, Johannes C. [VerfasserIn] |
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| | Weigel, Ralf [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Krauss, Joachim K. [VerfasserIn] |
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| Titel: | Rapid response of parkinsonian tremor to STN-DBS changes |
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| Titelzusatz: | direct modulation of oscillatory basal ganglia activity? |
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| Verf.angabe: | Christian Blahak, MD, Hansjörg Bäzner, MD, PhD, Hans-Holger Capelle, MD, Johannes C. Wöhrle, MD, PhD, Ralf Weigel, MD, PhD, Michael G. Hennerici, MD, PhD, and Joachim K. Krauss, MD, PhD |
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| E-Jahr: | 2009 |
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| Jahr: | [2009] |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 17.03.2021 |
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| Titel Quelle: | Enthalten in: Movement disorders |
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| Ort Quelle: | New York, NY : Wiley, 1986 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 24(2009), 8, Seite 1221-1225 |
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| ISSN Quelle: | 1531-8257 |
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| Abstract: | Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proved to be effective for tremor and other cardinal symptoms in Parkinson's disease (PD), the precise mechanisms of action of DBS are still unclear. We analyzed the time course of resting tremor amplitude and frequency during discontinuation and subsequent reinitiation of STN-DBS in nine PD patients, using a computerized three-dimensional motion analysis combined with surface electromyography. Following discontinuation of STN-DBS, resting tremor amplitude rapidly increased, reaching maximum amplitude after 2 min (mean ± 95%CI: 34.3 ± 13.8 mm; P < 0.01), subsequently stabilizing at a medium level. Reinitiation of stimulation after 30 min resulted in rapid, nearly complete suppression of tremor activity within 1 min (1.4 ± 1.3 mm; P < 0.01) and, furthermore, increased tremor frequency within a few seconds in seven of nine patients. These findings support the hypothesis that STN-DBS acts by direct interference with the neurotransmission of basal ganglia networks involved in tremor. © 2009 Movement Disorder Society |
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| DOI: | doi:10.1002/mds.22536 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/mds.22536 |
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| | DOI: https://doi.org/10.1002/mds.22536 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | deep brain stimulation |
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| | Parkinson's disease |
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| | subthalamic nucleus |
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| | tremor |
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| K10plus-PPN: | 1751594483 |
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| Verknüpfungen: | → Zeitschrift |
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Rapid response of parkinsonian tremor to STN-DBS changes / Blahak, Christian [VerfasserIn]; [2009] (Online-Ressource)
