Selective disruption of hippocampus-mediated recognition memory processes after episodes of transient global amnesia

• Verfasst von: Jäger, Theodor [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Griebe, Martin [VerfasserIn]
• Verfasst von: Bäzner, Hansjörg [VerfasserIn]
• Verfasst von: Möller, Johanna [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Titel: Selective disruption of hippocampus-mediated recognition memory processes after episodes of transient global amnesia
• Verf.angabe: Theodor Jäger, Kristina Szabo, Martin Griebe, Hansjörg Bäzner, Johanna Möller, Michael G. Hennerici
• E-Jahr: 2009
• Jahr: [2009]
• Jahr des Originals: 2008
• Umfang: 7 S.
• Fussnoten: Available online 22 August 2008 ; Gesehen am 17.03.2021
• Titel Quelle: Enthalten in: Neuropsychologia
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1963
• Jahr Quelle: 2009
• Band/Heft Quelle: 47(2009), 1, Seite 70-76
• ISSN Quelle: 1873-3514
• DOI: doi:10.1016/j.neuropsychologia.2008.08.019
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Familiarity
• Sach-SW: Hippocampal lesions
• Sach-SW: Recognition memory
• Sach-SW: Recollection
• Sach-SW: TGA
• Sach-SW: Transient global amnesia
• K10plus-PPN: 1751630781

Abstract

Transient global amnesia (TGA) is characterized by the abrupt onset of severe amnesia without concomitant focal neurological symptoms. Recent studies revealed that small and punctate MR-signal diffusion-weighted imaging (DWI) lesions can be found within the hippocampus of TGA patients during the post-acute phase. On the basis of dual-process models of recognition memory, the present study examined the hypothesis that hippocampal dysfunction as suggested by these DWI lesions disrupts hippocampus-mediated recollection in patients with TGA, whereas familiarity-based recognition memory that is assumed to be supported by extra-hippocampal brain regions should be unaffected. We administered a recognition memory task for faces and words to eleven TGA patients during the post-acute phase and to eleven matched controls. Receiver operating characteristics (ROCs) were obtained in order to derive estimates of familiarity and recollection by applying a formal dual-process model of recognition memory. Analyses of ROC curves revealed a disruption of recollection in TGA patients’ memory for words [t(20)=2.70, p<.05], but no difference in familiarity-based recognition memory between patients and controls [t(20)=−1.10, p=.284]. Post hoc analyses indicated that the deficit in recollection is more pronounced in TGA patients who show visible hippocampal lesions on diffusion-weighted MR imaging compared to those without detectable hippocampal lesions. In conclusion, consistent with recent neuroanatomical dual-process models of recognition memory, hippocampal dysfunction in patients with TGA is associated with a selective effect on specific recognition memory subprocesses.