| |  Online-Ressource |
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| Verfasst von: | Kleinschnitz, Christoph [VerfasserIn]  |
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| | Kraft, Peter [VerfasserIn] |
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| | Dreykluft, Angela [VerfasserIn] |
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| | Hagedorn, Ina [VerfasserIn] |
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| | Göbel, Kerstin [VerfasserIn] |
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| | Schuhmann, Michael K. [VerfasserIn] |
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| | Langhauser, Friederike [VerfasserIn] |
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| | Helluy, Xavier [VerfasserIn] |
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| | Schwarz, Tobias [VerfasserIn] |
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| | Bittner, Stefan [VerfasserIn] |
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| | Mayer, Christian T. [VerfasserIn] |
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| | Brede, Marc [VerfasserIn] |
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| | Varallyay, Csanad [VerfasserIn] |
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| | Pham, Mirko [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Jakob, Peter [VerfasserIn] |
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| | Magnus, Tim [VerfasserIn] |
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| | Meuth, Sven G. [VerfasserIn] |
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| | Iwakura, Yoichiro [VerfasserIn] |
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| | Zernecke, Alma [VerfasserIn] |
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| | Sparwasser, Tim [VerfasserIn] |
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| | Nieswandt, Bernhard [VerfasserIn] |
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| | Stoll, Guido [VerfasserIn] |
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| | Wiendl, Heinz [VerfasserIn] |
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| Titel: | Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature |
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| Verf.angabe: | Christoph Kleinschnitz, Peter Kraft, Angela Dreykluft, Ina Hagedorn, Kerstin Göbel, Michael K. Schuhmann, Friederike Langhauser, Xavier Helluy, Tobias Schwarz, Stefan Bittner, Christian T. Mayer, Marc Brede, Csanad Varallyay, Mirko Pham, Martin Bendszus, Peter Jakob, Tim Magnus, Sven G. Meuth, Yoichiro Iwakura, Alma Zernecke, Tim Sparwasser, Bernhard Nieswandt, Guido Stoll, and Heinz Wiendl |
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| Jahr: | 2013 |
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| Umfang: | 13 S. |
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| Fussnoten: | Prepublished online as Blood first edition paper, November 15, 2012 ; Gesehen am 08.06.2022 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 121(2013), 4, Seite 679-691 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | We have recently identified T cells as important mediators of ischemic brain damage, but the contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) are generally regarded as prototypic anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety of immune-mediated disorders. In the present study, we examined the role of Tregs after experimental brain ischemia/reperfusion injury. Selective depletion of Tregs in the DEREG mouse model dramatically reduced infarct size and improved neurologic function 24 hours after stroke and this protective effect was preserved at later stages of infarct development. The specificity of this detrimental Treg effect was confirmed by adoptive transfer experiments in wild-type mice and in Rag1−/− mice lacking lymphocytes. Mechanistically, Tregs induced microvascular dysfunction in vivo by increased interaction with the ischemic brain endothelium via the LFA-1/ICAM-1 pathway and platelets and these findings were confirmed in vitro. Ablation of Tregs reduced microvascular thrombus formation and improved cerebral reperfusion on stroke, as revealed by ultra-high-field magnetic resonance imaging at 17.6 Tesla. In contrast, established immunoregulatory characteristics of Tregs had no functional relevance. We define herein a novel and unexpected role of Tregs in a primary nonimmunologic disease state. |
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| DOI: | doi:10.1182/blood-2012-04-426734 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2012-04-426734 |
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| | DOI: https://doi.org/10.1182/blood-2012-04-426734 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1751720071 |
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| Verknüpfungen: | → Zeitschrift |
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Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature / Kleinschnitz, Christoph [VerfasserIn]; 2013 (Online-Ressource)
