On the etiology of incident brain lacunes

• Verfasst von: Gouw, Alida A. [VerfasserIn]
• Verfasst von: Flier, Wiesje M. van der [VerfasserIn]
• Verfasst von: Pantoni, Leonardo [VerfasserIn]
• Verfasst von: Inzitari, Domenico [VerfasserIn]
• Verfasst von: Erkinjuntti, Timo [VerfasserIn]
• Verfasst von: Wahlund, Lars O. [VerfasserIn]
• Verfasst von: Waldemar, Gunhild [VerfasserIn]
• Verfasst von: Schmidt, Reinhold [VerfasserIn]
• Verfasst von: Fazekas, Franz [VerfasserIn]
• Verfasst von: Scheltens, Philip [VerfasserIn]
• Verfasst von: Barkhof, Frederik [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Verfasst von: Blahak, Christian [VerfasserIn]
• Verfasst von: Bäzner, Hansjörg [VerfasserIn]
• Titel: On the etiology of incident brain lacunes
• Titelzusatz: longitudinal observations from the LADIS study
• Verf.angabe: Alida A. Gouw, MD, Wiesje M. van der Flier, PhD, Leonardo Pantoni, MD, Domenico Inzitari, MD, Timo Erkinjuntti, MD, Lars O. Wahlund, MD, PhD, Gunhild Waldemar, MD, DMSc, Reinhold Schmidt, MD, Franz Fazekas, MD, Philip Scheltens, MD, PhD, and Frederik Barkhof, MD, PhD
• E-Jahr: 2008
• Jahr: [November 2008]
• Umfang: 3 S.
• Fussnoten: List of participating centers and personnel: Helsinki, Finland (Memory Research Unit, Department of Clinical Neurosciences, Helsinki University): Timo Erkinjuntti, MD, PhD, Tarja Pohjasvaara, MD, PhD, Pia Pihanen, MD, Raija Ylikoski, PhD, Hanna Jokinen, PhD, Meija-Marjut Somerkoski, MPsych, Riitta Mäntylä, MD, PhD, Oili Salonen, MD, PhD; Graz, Austria (Department of Neurology and Department of Radiology, Division of Neuroradiology, Medical University Graz): Franz Fazekas, MD, Reinhold Schmidt, MD, Stefan Ropele, PhD, Brigitte Rous, MD, Katja Petrovic, MagPsychol, Ulrike Garmehi, Alexandra Seewann, MD; Lisboa, Portugal (Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria): José M. Ferro, MD, PhD, Ana Verdelho, MD, Sofia Madureira, PsyD, Carla Moleiro, PhD; Amsterdam, The Netherlands (Department of Radiology and Neurology, VU Medical Center): Philip Scheltens, MD, PhD, Ilse van Straaten, MD, Frederik Barkhof, MD, PhD, Alida Gouw, MD, Wiesje van der Flier, PhD; Goteborg, Sweden (Institute of Clinical Neuroscience, Goteborg University): Anders Wallin, MD, PhD, Michael Jonsson, MD, Karin Lind, MD, Arto Nordlund, PsyD, Sindre Rolstad, PsyD, Ingela Isblad, RN; Huddinge, Sweden (Karolinska Institutet, Department of Neurobiology, Care Sciences and Society. Karolinska University Hospital Huddinge.): Lars-Olof Wahlund, MD, PhD, Milita Crisby, MD, PhD, Anna Pettersson, RPT, PhD, Kaarina Amberla, PsyD; Paris, France (Department of Neurology, Hopital Lariboisiere): Hugues Chabriat, MD, PhD, Karen Hernandez, psychologist, Annie Kurtz, psychologist, Dominique Hervé, MD, Sarah Benisty, MD, Jean Pierre Guichard, MD; Mannheim, Germany (Department of Neurology, University of Heidelberg, Klinikum Mannheim): Michael Hennerici, MD, Christian Blahak, MD, Hansjorg Baezner, MD, Martin Wiarda, PsyD, Susanne Seip, RN; Copenhagen, Denmark (Memory Disorders Research Group, Department of Neurology, Rigshospitalet, and the Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Copenhagen University Hospitals): Gunhild Waldemar, MD, DMSc, Egill Rostrup, MD, MSc; Charlotte Ryberg, MSc, Tim Dyrby MSc, Olaf B. Paulson, MD, DMSc; Newcastle-on-Tyne, UK (Institute for Ageing and Health, University of Newcastle): John O'Brien, DM, Sanjeet Pakrasi, MRCPsych, Mani Krishnan MRCPsych, Andrew Teodorczuk, MRCPsych, Michael Firbank, PhD, Philip English, DCR, Thais Minett, MD, PhD ; Gesehen am 24.03.2021
• Titel Quelle: Enthalten in: Stroke
• Ort Quelle: New York, NY : Association, 1970
• Jahr Quelle: 2008
• Band/Heft Quelle: 39(2008), 11 vom: Nov., Seite 3083-3085
• ISSN Quelle: 1524-4628
• DOI: doi:10.1161/STROKEAHA.108.521807
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1752303040

Abstract

Background and Purpose— We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.Methods— Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.Results— 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.Conclusion— Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.