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| Verfasst von: | Ryberg, Charlotte [VerfasserIn]  |
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| | Rostrup, E. [VerfasserIn] |
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| | Sjöstrand, K. [VerfasserIn] |
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| | Paulson, O. B. [VerfasserIn] |
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| | Barkhof, F. [VerfasserIn] |
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| | Scheltens, P. [VerfasserIn] |
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| | Straaten, E. C. W. van [VerfasserIn] |
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| | Fazekas, F. [VerfasserIn] |
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| | Schmidt, R. [VerfasserIn] |
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| | Erkinjuntti, T. [VerfasserIn] |
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| | Wahlund, L.-O. [VerfasserIn] |
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| | Basile, A. M. [VerfasserIn] |
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| | Pantoni, L. [VerfasserIn] |
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| | Inzitari, D. [VerfasserIn] |
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| | Waldemar, G. [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Blahak, Christian [VerfasserIn] |
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| | Bäzner, Hansjörg [VerfasserIn] |
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| Titel: | White matter changes contribute to corpus callosum atrophy in the elderly |
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| Titelzusatz: | the LADIS study |
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| Verf.angabe: | C. Ryberg, E. Rostrup, K. Sjöstrand, O.B. Paulson, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, R. Schmidt, T. Erkinjuntti, L.-O. Wahlund, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar |
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| E-Jahr: | 2008 |
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| Jahr: | [Sep 2008] |
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| Umfang: | 7 S. |
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| Fussnoten: | List of participating centers and personnel: Timo Erkinjuntti, MD, PhD, Michael Hennerici, MD, Christian Blahak, MD, Hansjorg Baezner, MD [und weitere] ; Gesehen am 24.03.2021 |
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| Titel Quelle: | Enthalten in: American journal of neuroradiology |
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| Ort Quelle: | Oak Brook, Ill. : Soc., 1980 |
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| Jahr Quelle: | 2008 |
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| Band/Heft Quelle: | 29(2008), 8, Seite 1498-1504 |
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| ISSN Quelle: | 1936-959X |
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| Abstract: | BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects. - MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions. The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions. - RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy. - CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue. |
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| DOI: | doi:10.3174/ajnr.A1169 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3174/ajnr.A1169 |
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| | Volltext: http://www.ajnr.org/content/29/8/1498 |
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| | DOI: https://doi.org/10.3174/ajnr.A1169 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1752321537 |
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| Verknüpfungen: | → Zeitschrift |
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White matter changes contribute to corpus callosum atrophy in the elderly / Ryberg, Charlotte [VerfasserIn]; [Sep 2008] (Online-Ressource)
