Formation of a polymer surface with a gradient of pore size using a microfluidic chip

• Verfasst von: Kreppenhofer, Kristina [VerfasserIn]
• Verfasst von: Li, Junsheng [VerfasserIn]
• Verfasst von: Segura, Rodrigo [VerfasserIn]
• Verfasst von: Popp, Ludmilla [VerfasserIn]
• Verfasst von: Rossi, Massimiliano [VerfasserIn]
• Verfasst von: Tzvetkova, Pavleta [VerfasserIn]
• Verfasst von: Luy, Burkhard [VerfasserIn]
• Verfasst von: Kähler, Christian J. [VerfasserIn]
• Verfasst von: Guber, Andreas E. [VerfasserIn]
• Verfasst von: Levkin, Pavel [VerfasserIn]
• Titel: Formation of a polymer surface with a gradient of pore size using a microfluidic chip
• Verf.angabe: Kristina Kreppenhofer, Junsheng Li, Rodrigo Segura, Ludmilla Popp, Massimiliano Rossi, Pavleta Tzvetkova, Burkhard Luy, Christian J. Kähler, Andreas E. Guber, and Pavel A. Levkin
• E-Jahr: 2013
• Jahr: February 21, 2013
• Umfang: 8 S.
• Teil: volume:29
• Teil: year:2013
• Teil: number:11
• Teil: pages:3797-3804
• Teil: extent:8
• Fussnoten: Gesehen am 31.03.2021
• Titel Quelle: Enthalten in: Langmuir
• Ort Quelle: Washington, DC : ACS Publ., 1985
• Jahr Quelle: 2013
• Band/Heft Quelle: 29(2013), 11, Seite 3797-3804
• ISSN Quelle: 1520-5827
• DOI: doi:10.1021/la304997a
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 175273744X

Abstract

Here we demonstrate the generation of polymer monolithic surfaces possessing a gradient of pore and polymer globule sizes from ∼0.1 to ∼0.5 μm defined by the composition of two polymerization mixtures injected into a microfluidic chip. To generate the gradient, we used a PDMS microfluidic chip with a cascade micromixer with a subsequent reaction chamber for the formation of a continuous gradient film. The micromixer has zigzag channels of 400 × 680 μm2 cross section and six cascades. The chip was used with a reversible bonding connection, realized by curing agent coating. After polymerization in the microfluidic chip the reversible bond was opened, resulting in a 450 μm thick polymer film possessing the pore size gradient. The gradient formation in the microfluidic reaction chamber was studied using microscopic laser-induced fluorescence (μLIF) and different model fluids. Formation of linear gradients was shown using the fluids of the same density by both diffusive mixing at flow rates of 0.001 mL/min and in a convective mixing regime at flow rates of 20 mL/min. By using different density fluids, formation of a two-dimensional wedge-like gradient controlled by the density difference and orientation of the microfluidic chip was observed.