| |  Online-Ressource |
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| Verfasst von: | Krieg, Peter [VerfasserIn]  |
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| | Rosenberger, Sabine [VerfasserIn] |
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| | Juanes, Silvia de [VerfasserIn] |
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| | Latzko, Susanne [VerfasserIn] |
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| | Hou, Jin [VerfasserIn] |
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| | Dick, Angela [VerfasserIn] |
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| | Kloz, Ulrich [VerfasserIn] |
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| | van der Hoeven, Frank [VerfasserIn] |
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| | Haußer-Siller, Ingrid [VerfasserIn] |
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| | Esposito, Irene [VerfasserIn] |
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| | Rauh, Manfred [VerfasserIn] |
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| | Schneider, Holm [VerfasserIn] |
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| Titel: | Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation |
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| Verf.angabe: | Peter Krieg, Sabine Rosenberger, Silvia de Juanes, Susanne Latzko, Jin Hou, Angela Dick, Ulrich Kloz, Frank van der Hoeven, Ingrid Hausser, Irene Esposito, Manfred Rauh and Holm Schneider |
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| Jahr: | 2013 |
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| Jahr des Originals: | 2012 |
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| Umfang: | 9 S. |
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| Teil: | volume:133 |
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| | year:2013 |
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| | number:1 |
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| | pages:172-180 |
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| | extent:9 |
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| Fussnoten: | Published online 26 July 2012 ; Gesehen am 31.03.2021 |
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| Titel Quelle: | Enthalten in: The journal of investigative dermatology |
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| Ort Quelle: | Amsterdam : Elsevier, 1938 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 133(2013), 1, Seite 172-180 |
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| ISSN Quelle: | 1523-1747 |
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| Abstract: | Loss-of-function mutations in the lipoxygenase (LOX) genes ALOX12B and ALOXE3 are the second most common cause of autosomal recessive congenital ichthyosis. The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation. Here, we show that eLOX-3 deficiency in mice results in early postnatal death, associated with similar but somewhat less severe barrier defects and morphological changes than reported earlier for the 12R-LOX-knockout mice. Skin lipid analysis demonstrated that the severity of barrier failure is related to the loss of covalently bound ceramides in both 12R-LOX- and eLOX-3-null mice, confirming a proposed functional linkage of the LOX pathway to ceramide processing and formation of the corneocyte lipid envelope. Furthermore, analysis of free oxygenated fatty acid metabolites revealed strongly reduced levels of hepoxilin metabolites in eLOX-3-deficient epidermis, indicating an additional function of eLOX-3 in mammalian skin as a hepoxilin synthase linked to the 12S-LOX pathway. |
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| DOI: | doi:10.1038/jid.2012.250 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/jid.2012.250 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X15359480 |
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| | DOI: https://doi.org/10.1038/jid.2012.250 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1752775112 |
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| Verknüpfungen: | → Zeitschrift |
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Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation / Krieg, Peter [VerfasserIn]; 2013 (Online-Ressource)
