| Online-Ressource |
Verfasst von: | Wortmann, Markus [VerfasserIn]  |
| Arshad, Muhammad [VerfasserIn]  |
| Peters, Andreas [VerfasserIn]  |
| Hakimi, Maani [VerfasserIn]  |
| Böckler, Dittmar [VerfasserIn]  |
| Dihlmann, Susanne [VerfasserIn]  |
Titel: | The C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N |
Verf.angabe: | Markus Wortmann, Muhammad Arshad, Andreas S. Peters, Maani Hakimi, Dittmar Böckler, Susanne Dihlmann |
Jahr: | 2021 |
Jahr des Originals: | 2020 |
Umfang: | 6 S. |
Fussnoten: | Available online 1 December 2020 ; Gesehen am 30.03.2021 |
Titel Quelle: | Enthalten in: Atherosclerosis |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 318(2021) vom: Feb., Seite 8-13 |
ISSN Quelle: | 1879-1484 |
Abstract: | Background and aims - Genetic variations between C57Bl/6 mouse substrains are highly relevant to the investigation of cardiovascular disease. We here assessed whether these variations have an impact on the incidence of abdominal aortic aneurysms (AAA) in C57Bl/6J and 6 N mice. - Methods - AAA were induced by subcutaneous infusion of 1500 ng/kg*min Angiotensin-II for four weeks in six-month-old male CB57Bl/6J and 6N mice. Aortic smooth muscle cells (VSMC) were isolated from untreated animals for in vitro analysis. - Results - C57Bl/6J mice are more susceptible to AAA formation (76.5% vs. 7.1%, p = 0.0002). C57Bl/6J VSMC expressed more pro-inflammatory molecules such as Nlrp3, Aim2 and NF-κB. Additionally, these cells presented significantly higher levels of NADP/NADPH and oxidative DNA modifications, as indicated by 8-OHdG-staining, compared to C57Bl/6N VSMC. - Conclusions - In contrast to previous reports, we present evidence that six-month-old C57BL/6J, but not C57BL/6N mice develop AAA. In accordance with the deficiency of nicotinamide-nucleotide-transhydrogenase (Nnt), C57BL/6J VSMC displayed increased oxidative stress, oxidative DNA damage and a stronger inflammatory phenotype than C57BL/6N VSMC. |
DOI: | doi:10.1016/j.atherosclerosis.2020.11.032 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.atherosclerosis.2020.11.032 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0021915020315525 |
| DOI: https://doi.org/10.1016/j.atherosclerosis.2020.11.032 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Angiotensin II |
| Aortic aneurysm |
| C57Bl/6J |
| C57Bl/6N |
K10plus-PPN: | 1752820983 |
Verknüpfungen: | → Zeitschrift |
¬The¬ C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N / Wortmann, Markus [VerfasserIn]; 2021 (Online-Ressource)