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Status: Bibliographieeintrag

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Verfasst von:Mancarella, Daniela [VerfasserIn]   i
 Plass, Christoph [VerfasserIn]   i
Titel:Epigenetic signatures in cancer
Titelzusatz:proper controls, current challenges and the potential for clinical translation
Verf.angabe:Daniela Mancarella and Christoph Plass
E-Jahr:2021
Jahr:10 February 2021
Umfang:12 S.
Teil:volume:13
 year:2021
 elocationid:23
 pages:1-12
 extent:12
Fussnoten:Gesehen am 30.03.2021
Titel Quelle:Enthalten in: Genome medicine
Ort Quelle:London : BioMed Central, 2009
Jahr Quelle:2021
Band/Heft Quelle:13(2021), Artikel-ID 23, Seite 1-12
ISSN Quelle:1756-994X
Abstract:Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues found alterations in patterns of DNA methylation, histone posttranslational modifications, and changes in chromatin accessibility. Driven by sophisticated, next-generation sequencing-based technologies, recent studies discovered cancer epigenomes to be dominated by epigenetic patterns already present in the cell-of-origin, which transformed into a neoplastic cell. Tumor-specific epigenetic changes therefore need to be redefined and factors influencing epigenetic patterns need to be studied to unmask truly disease-specific alterations. The underlying mechanisms inducing cancer-associated epigenetic alterations are poorly understood. Studies of mutated epigenetic modifiers, enzymes that write, read, or edit epigenetic patterns, or mutated chromatin components, for example oncohistones, help to provide functional insights on how cancer epigenomes arise. In this review, we highlight the importance and define challenges of proper control tissues and cell populations to exploit cancer epigenomes. We summarize recent advances describing mechanisms leading to epigenetic changes in tumorigenesis and briefly discuss advances in investigating their translational potential.
DOI:doi:10.1186/s13073-021-00837-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1186/s13073-021-00837-7
 DOI: https://doi.org/10.1186/s13073-021-00837-7
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cancer
 Cell-of-origin
 Epigenetic signatures
 Epigenetic therapy
 Epigenomics
 Oncohistones
 Precision oncology
 Tumor subclassification
K10plus-PPN:1752825241
Verknüpfungen:→ Zeitschrift

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