| |  Online-Ressource |
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| Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
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| | Simons, M. [VerfasserIn] |
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| | Bergmann, Carina [VerfasserIn] |
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| | Stroick, Mark Gregor [VerfasserIn] |
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| | Lütjohann, D. [VerfasserIn] |
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| | Keller, P. [VerfasserIn] |
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| | Runz, Heiko [VerfasserIn] |
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| | Kühl, Sandra [VerfasserIn] |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Bergmann, K. von [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Beyreuther, Konrad [VerfasserIn] |
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| | Hartmann, Tobias [VerfasserIn] |
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| Titel: | Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo |
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| Verf.angabe: | K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, S. Kühl, T. Bertsch, K. von Bergmann, M. Hennerici, K. Beyreuther, and T. Hartmann |
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| E-Jahr: | 2001 |
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| Jahr: | [May 8, 2001] |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 31.03.2021 |
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| Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
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| Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 98(2001), 10 vom: Mai, Seite 5856-5861 |
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| ISSN Quelle: | 1091-6490 |
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| Abstract: | Recent epidemiological studies show a strong reduction in the - incidence of Alzheimer's disease in patients treated with - cholesterol-lowering statins. Moreover, elevated Aβ42 levels and the - ɛ4 allele of the lipid-carrier apolipoprotein E are regarded as risk - factors for sporadic and familial Alzheimer's disease. Here we - demonstrate that the widely used cholesterol-lowering drugs simvastatin - and lovastatin reduce intracellular and extracellular levels of Aβ42 - and Aβ40 peptides in primary cultures of hippocampal neurons and - mixed cortical neurons. Likewise, guinea pigs treated with high doses - of simvastatin showed a strong and reversible reduction of cerebral - Aβ42 and Aβ40 levels in the cerebrospinal fluid and brain - homogenate. These results suggest that lipids are playing an important - role in the development of Alzheimer's disease. Lowered levels of - Aβ42 may provide the mechanism for the observed reduced incidence of - dementia in statin-treated patients and may open up avenues for - therapeutic interventions. |
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| DOI: | doi:10.1073/pnas.081620098 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1073/pnas.081620098 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC33303/ |
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| | DOI: https://doi.org/10.1073/pnas.081620098 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1752919033 |
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| Verknüpfungen: | → Zeitschrift |
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Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo / Faßbender, Klaus [VerfasserIn]; [May 8, 2001] (Online-Ressource)
