| Online-Ressource |
Verfasst von: | Held, Gerhard Wolfgang [VerfasserIn]  |
| Zeynalova, Samira [VerfasserIn]  |
| Murawski, Niels [VerfasserIn]  |
| Ziepert, Marita [VerfasserIn]  |
| Kempf, Barbara [VerfasserIn]  |
| Viardot, Andreas [VerfasserIn]  |
| Dreyling, Martin [VerfasserIn]  |
| Hallek, Michael [VerfasserIn]  |
| Witzens-Harig, Mathias [VerfasserIn]  |
| Fleckenstein, Jochen [VerfasserIn]  |
| Rübe, Christian [VerfasserIn]  |
| Zwick, Carsten [VerfasserIn]  |
| Glass, Bertram [VerfasserIn]  |
| Schmitz, Norbert [VerfasserIn]  |
| Pfreundschuh, Michael [VerfasserIn]  |
Titel: | Impact of rituximab and radiotherapy on outcome of patients with aggressive B-Cell lymphoma and skeletal iInvolvement |
Verf.angabe: | Gerhard Held, Samira Zeynalova, Niels Murawski, Marita Ziepert, Barbara Kempf, Andreas Viardot, Martin Dreyling, Michael Hallek, Mathias Witzens-Harig, Jochen Fleckenstein, Christian Rübe, Carsten Zwick, Bertram Glass, Norbert Schmitz, and Michael Pfreundschuh |
E-Jahr: | 2013 |
Jahr: | September 23, 2013 |
Umfang: | 8 S. |
Teil: | volume:31 |
| year:2013 |
| number:32 |
| pages:4115-4122 |
| extent:8 |
Fussnoten: | Gesehen am 31.03.2021 |
Titel Quelle: | Enthalten in: Journal of clinical oncology |
Ort Quelle: | Alexandria, Va. : American Society of Clinical Oncology, 1983 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 31(2013), 32, Seite 4115-4122 |
ISSN Quelle: | 1527-7755 |
Abstract: | Purpose To study clinical presentation, outcome, and the role of radiotherapy in patients with aggressive B-cell lymphoma and skeletal involvement treated with and without rituximab. Patients and Methods Outcome of patients with skeletal involvement was analyzed in a retrospective study of nine consecutive prospective trials of the German High-Grade Non-Hodgkin lymphoma Study Group. Results Of 3,840 patients, 292 (7.6%) had skeletal involvement. In the MabThera International Trial (MInT) for young good-prognosis patients and the Rituximab With CHOP Over 60 Years (RICOVER-60) study for elderly patients, the randomized addition of rituximab improved event-free survival (EFS; hazard ratio for MInT [HRMInT] = 0.4, P > 001; hazard ratio for RICOVER-60 [HRRICOVER-60] = 0.6, P > .001) and overall survival (OS; HRMInT = 0.4, P < .001; HRRICOVER-60 = 0.7, P = .002) in patients without skeletal involvement, but failed to improve the outcome of patients with skeletal involvement (EFS: HRMInT = 1.4, P = .444; HRRICOVER-60 = 0.8, P = .449; OS: HRMInT = 0.6, P = .449; HRRICOVER-60 = 1.0, P = .935). Skeletal involvement was associated with a worse outcome after cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus rituximab (HREFS = 1.5, P = .048; HROS = 1.1; P = .828), but not after CHOP without rituximab (HREFS = 0.8, P = .181; HROS = 0.7, P = .083). In contrast to rituximab, additive radiotherapy to sites of skeletal involvement was associated with a decreased risk (HREFS = 0.3, P = .001; HROS = 0.5; P = .111). Conclusion Rituximab failed to improve the outcome of patients with diffuse large B-cell lymphoma with skeletal involvement, although our data suggest a beneficial effect of radiotherapy to sites of skeletal involvement. Whether radiotherapy to sites of skeletal involvement can be spared in cases with a negative positron emission tomography after immunochemotherapy should be addressed in appropriately designed prospective trials. |
DOI: | doi:10.1200/JCO.2012.48.0467 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1200/JCO.2012.48.0467 |
| Volltext: https://ascopubs.org/doi/10.1200/JCO.2012.48.0467 |
| DOI: https://doi.org/10.1200/JCO.2012.48.0467 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1752982959 |
Verknüpfungen: | → Zeitschrift |
Impact of rituximab and radiotherapy on outcome of patients with aggressive B-Cell lymphoma and skeletal iInvolvement / Held, Gerhard Wolfgang [VerfasserIn]; September 23, 2013 (Online-Ressource)