| |  Online-Ressource |
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| Verfasst von: | Tanner, Michael Christopher [VerfasserIn]  |
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| | Boxriker, Sonja [VerfasserIn] |
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| | Haubruck, Patrick [VerfasserIn] |
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| | Child, Christopher [VerfasserIn] |
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| | Westhauser, Fabian [VerfasserIn] |
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| | Fischer, Christian [VerfasserIn] |
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| | Schmidmaier, Gerhard [VerfasserIn] |
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| | Moghaddam-Alvandi, Arash [VerfasserIn] |
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| Titel: | Expression of VEGF in peripheral serum is a possible prognostic factor in bone-regeneration via Masquelet-technique |
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| Titelzusatz: | a pilot study |
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| Verf.angabe: | Michael C. Tanner, Sonja Boxriker, Patrick Haubruck, Christopher Child, Fabian Westhauser, Christian Fischer, Gerhard Schmidmaier and Arash Moghaddam |
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| E-Jahr: | 2021 |
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| Jahr: | 15 February 2021 |
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| Umfang: | 11 S. |
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| Teil: | volume:10 |
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| | year:2021 |
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| | number:4 |
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| | elocationid:776 |
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| | pages:1-11 |
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| | extent:11 |
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| Fussnoten: | Gesehen am 10.09.2021 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 10(2021), 4, Artikel-ID 776, Seite 1-11 |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Two-step Masquelet-technique established a new procedure in the treatment of osseous defects, addressing prerequisites postulated by the “diamond concept”. Increase in blood perfusion and growth factors are enhanced by the “Masquelet-membrane”. To describe this, we measured serum levels of Vascular Endothelial Growth Factor (VEGF) of patients with atrophic non-unions of long bones undergoing Masquelet-technique. From over 500 non-union patients undergoing Masquelet-technique with prospective follow-up we randomly selected 30 patients. 23 were included, 7 lost to follow-up or excluded because of incomplete data. Serum was drawn at specified intervals before and after surgery. Patients were followed for at least 6 months after step 2. Classification into both groups was performed according to radiological results and clinical outcome 6 months after step 2. Concentration of VEGF in patients’ serum was performed via ELISA. 14 achieved osseous consolidation (responder group), 9 cases did not (non-responder). Responders showed a significant increase of serum-VEGF in the first and second week when compared to the preoperative values of step 1. Non-responders showed a significant increase of VEGF in the second week after Steps 1 and 2. Comparison of groups showed significantly higher increase of serum-VEGF week2 after step 1 and preoperative to step 2 for responders. Results show one possibility of illustrating therapeutic progress by monitoring growth factors and possibly allowing prognostic conclusions thereof. This might lead to a more targeted treatment protocol. |
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| DOI: | doi:10.3390/jcm10040776 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/jcm10040776 |
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| | Volltext: https://www.mdpi.com/2077-0383/10/4/776 |
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| | DOI: https://doi.org/10.3390/jcm10040776 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | bone regeneration |
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| | induced membrane |
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| | Masquelet-technique |
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| | non-union |
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| | VEGF |
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| K10plus-PPN: | 1753032806 |
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| Verknüpfungen: | → Zeitschrift |
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Expression of VEGF in peripheral serum is a possible prognostic factor in bone-regeneration via Masquelet-technique / Tanner, Michael Christopher [VerfasserIn]; 15 February 2021 (Online-Ressource)
