Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin

• Verfasst von: Roser, Christoph [VerfasserIn]
• Verfasst von: Tóth, Csaba [VerfasserIn]
• Verfasst von: Renner, Marcus [VerfasserIn]
• Verfasst von: Herpel, Esther [VerfasserIn]
• Verfasst von: Schirmacher, Peter [VerfasserIn]
• Titel: Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin
• Verf.angabe: Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel and Peter Schirmacher
• E-Jahr: 2021
• Jahr: 12 February 2021
• Umfang: 11 S.
• Fussnoten: Gesehen am 01.04.2021
• Titel Quelle: Enthalten in: Cell communication and signaling
• Ort Quelle: London : Biomed Central, 2003
• Jahr Quelle: 2021
• Band/Heft Quelle: 19(2021), Artikel-ID 15, Seite 1-11
• ISSN Quelle: 1478-811X
• DOI: doi:10.1186/s12964-020-00702-x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apoptosis
• Sach-SW: ARC
• Sach-SW: Bcl-2
• Sach-SW: COX-2
• Sach-SW: FAP
• Sach-SW: Mismatch repair protein
• Sach-SW: p53
• Sach-SW: β-catenin
• K10plus-PPN: 175311375X
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Colorectal familial adenomatous polyposis (FAP) adenomas exhibit a uniform pathogenetic basis caused by a germline mutation in the adenomatous polyposis gene (APC), but the molecular changes leading to their development are incompletely understood. However, dysregulated apoptosis is known to substantially affect the development of colonic adenomas. One of the key regulatory proteins involved in apoptosis is apoptosis repressor with caspase recruitment domain (ARC).