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Status: Bibliographieeintrag

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Verfasst von:Went, Molly [VerfasserIn]   i
 Cornish, Alex J. [VerfasserIn]   i
 Law, Philip J. [VerfasserIn]   i
 Kinnersley, Ben [VerfasserIn]   i
 van Duin, Mark [VerfasserIn]   i
 Weinhold, Niels [VerfasserIn]   i
 Försti, Asta [VerfasserIn]   i
 Hansson, Markus [VerfasserIn]   i
 Sonneveld, Pieter [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Morgan, Gareth J. [VerfasserIn]   i
 Hemminki, Kari [VerfasserIn]   i
 Nilsson, Björn [VerfasserIn]   i
 Kaiser, Martin [VerfasserIn]   i
 Houlston, Richard S. [VerfasserIn]   i
Titel:Search for multiple myeloma risk factors using Mendelian randomization
Verf.angabe:Molly Went, Alex J. Cornish, Philip J. Law, Ben Kinnersley, Mark van Duin, Niels Weinhold, Asta Försti, Markus Hansson, Pieter Sonneveld, Hartmut Goldschmidt, Gareth J. Morgan, Kari Hemminki, Björn Nilsson, Martin Kaiser, and Richard S. Houlston
E-Jahr:2020
Jahr:20 May 2020
Umfang:8 S.
Teil:volume:4
 year:2020
 number:10
 month:05
 pages:2172-2179
 extent:8
Fussnoten:Gesehen am 06.04.2021
Titel Quelle:Enthalten in: Blood advances
Ort Quelle:Washington, DC : American Society of Hematology, 2016
Jahr Quelle:2020
Band/Heft Quelle:4(2020), 10 vom: Mai, Seite 2172-2179
ISSN Quelle:2473-9537
Abstract:The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS of 7717 MM cases and 29 304 controls. Odds ratios (ORs) per 1 standard deviation increase in each phenotype were estimated under an inverse variance weighted random effects model. A Bonferroni-corrected threshold of P = 2 × 10−4 was considered significant, whereas P < .05 was considered suggestive of an association. Although no significant associations with MM risk were observed among the 249 phenotypes, 28 phenotypes showed evidence suggestive of association, including increased levels of serum vitamin B6 and blood carnitine (P = 1.1 × 10−3) with greater MM risk and ω-3 fatty acids (P = 5.4 × 10−4) with reduced MM risk. A suggestive association between increased telomere length and reduced MM risk was also noted; however, this association was primarily driven by the previously identified risk variant rs10936599 at 3q26 (TERC). Although not statistically significant, increased body mass index was associated with increased risk (OR, 1.10; 95% confidence interval, 0.99-1.22), supporting findings from a previous meta-analysis of prospective observational studies. Our study did not provide evidence supporting any modifiable factors examined as having a major influence on MM risk; however, it provides insight into factors for which the evidence has previously been mixed.
DOI:doi:10.1182/bloodadvances.2020001502
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1182/bloodadvances.2020001502
 Volltext: https://ashpublications.org/bloodadvances/article/4/10/2172/456021/Search-for-multiple-myeloma-risk-factors-using
 DOI: https://doi.org/10.1182/bloodadvances.2020001502
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1753141370
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