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Verfasst von:Zhang, Zhenfeng [VerfasserIn]   i
 Urban, Stephan [VerfasserIn]   i
Titel:New insights into HDV persistence
Titelzusatz:the role of interferon response and implications for upcoming novel therapies
Verf.angabe:Zhenfeng Zhang, Stephan Urban
Jahr:2021
Umfang:14 S.
Teil:volume:74
 year:2021
 number:3
 pages:686-699
 extent:14
Fussnoten:Available online1 December 2020 ; Gesehen am 09.09.2021
Titel Quelle:Enthalten in: Journal of hepatology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2021
Band/Heft Quelle:74(2021), 3, Seite 686-699
ISSN Quelle:1600-0641
Abstract:Chronic hepatitis D (CHD), a global health problem, manifests as the most severe form of viral hepatitis. The causative agent, HDV, is the smallest known human virus; it replicates its circular single-stranded RNA genome in the nucleus of hepatocytes. HDV requires HBV-encoded envelope proteins for dissemination and de novo cell entry. However, HDV can also spread through cell division. Following entry into hepatocytes, replicative intermediates of HDV RNA are sensed by the pattern recognition receptor MDA5 (melanoma differentiation antigen 5) resulting in interferon (IFN)-β/λ induction. This IFN response strongly suppresses cell division-mediated spread of HDV genomes, however, it only marginally affects HDV RNA replication in already infected, resting hepatocytes. Monotherapy with IFN-α/λ shows efficacy but rarely results in HDV clearance. Recent molecular insights into key determinants of HDV persistence and the accelerated development of specifically acting antivirals that interfere with the replication cycle have revealed promising new therapeutic perspectives. In this review, we briefly summarise our knowledge on replication/persistence of HDV, the newly discovered HDV-like agents, and the interplay of HDV with the IFN response and its consequences for persistence. Finally, we discuss the possible role of IFNs in combination with upcoming therapies aimed at HDV cure.
DOI:doi:10.1016/j.jhep.2020.11.032
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.jhep.2020.11.032
 Volltext: https://www.sciencedirect.com/science/article/pii/S0168827820338198
 DOI: https://doi.org/10.1016/j.jhep.2020.11.032
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell division-mediated spread
 Hepatitis B virus
 Hepatitis D virus
 Hepcludex/Bulevirtide
 Innate immunity
 Interferon response
 Myrcludex B
 Persistence
 Spreading pathways
K10plus-PPN:1753143411
Verknüpfungen:→ Zeitschrift

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