Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Finzer, Patrick [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
| Rösl, Frank [VerfasserIn]  |
Titel: | HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway |
Verf.angabe: | Patrick Finzer, Andreas Krueger, Michael Stöhr, Dirk Brenner, Ubaldo Soto, Christian Kuntzen, Peter H. Krammer and Frank Rösl |
E-Jahr: | 2004 |
Jahr: | 12 April 2004 |
Umfang: | 11 S. |
Teil: | volume:23 |
| year:2004 |
| number:28 |
| pages:4807-4817 |
| extent:11 |
Fussnoten: | Gesehen am 06.04.2021 |
Titel Quelle: | Enthalten in: Oncogene |
Ort Quelle: | London : Springer Nature, 1997 |
Jahr Quelle: | 2004 |
Band/Heft Quelle: | 23(2004), 28, Seite 4807-4817 |
ISSN Quelle: | 1476-5594 |
Abstract: | Histone deacetylase (HDAC) inhibitors induce an intrinsic type of apoptosis in human papillomavirus (HPV)-positive cells by disrupting the mitochondrial transmembrane potential (ΔΨm). Loss of ΔΨm was only detected in E7, but not in E6 oncogene-expressing cells. HDAC inhibition led to a time-dependent degradation of the pocket proteins pRb, p107 and p130, releasing ‘free’ E2F-1 following initial G1 arrest. Inhibition of proteasomal proteolysis, but not of caspase activity rescued pRb from degradation and functionally restored its inhibitory effect on the cyclin E gene, known to be suppressed by pRb-E2F-1 in conjunction with HDAC1. Using siRNA targeted against p53, E2F-1 still triggered apoptosis by inducing the E2F-responsive proapoptotic α- and β-isoforms of p73. These data may determine future therapeutic strategies in which HDAC inhibitors can effectively eliminate HPV-positive cells by an apoptotic route that does not rely on the reactivation of the ‘classical’ p53 pathway through a preceding shut-off of viral gene expression. |
DOI: | doi:10.1038/sj.onc.1207620 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.onc.1207620 |
| Volltext: https://www.nature.com/articles/1207620 |
| DOI: https://doi.org/10.1038/sj.onc.1207620 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1753148677 |
Verknüpfungen: | → Zeitschrift |
HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway / Finzer, Patrick [VerfasserIn]; 12 April 2004 (Online-Ressource)
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