Status: Bibliographieeintrag
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| Verfasst von: | Eichhorst, Sören [VerfasserIn]  |
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| | Golks, Alexander [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| Titel: | Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice |
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| Verf.angabe: | Sören T. Eichhorst, Andreas Krueger, Susanne Müerköster, Stefanie C. Fas, Alexander Golks, Uwe Gruetzner, Louise Schubert, Christine Opelz, Manfred Bilzer, Alexander L. Gerbes & Peter H. Krammer |
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| E-Jahr: | 2004 |
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| Jahr: | 16 May 2004 |
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| Umfang: | 8 S. |
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| Teil: | volume:10 |
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| | year:2004 |
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| | number:6 |
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| | month:06 |
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| | pages:602-609 |
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| | extent:8 |
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| Fussnoten: | Gesehen am 06.04.2021 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | New York, NY : Nature America Inc., 1995 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 10(2004), 6 vom: Juni, Seite 602-609 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | Suramin is a polysulfonated derivative of urea and has been widely used both to treat infections and as a chemotherapeutic drug. Suramin has been shown to inhibit growth factor signaling pathways; however, its effect on apoptosis is unknown. Here we show that suramin inhibits apoptosis induced through death receptors in hepatoma and lymphoma cells. It also inhibits the proapoptotic effect of chemotherapeutic drugs. The antiapoptotic mechanism is specific to cell type and is caused by reduced activation, but not altered composition, of the death-inducing signaling complex (DISC), and by inhibition of the initiator caspases 8, 9 and 10. Suramin also shows similar effects in in vivo models: apoptotic liver damage induced by CD95 stimulation and endotoxic shock mediated by tumor-necrosis factor (TNF) are inhibited in mice, but necrotic liver damage is not inhibited in a rat model of liver transplantation. Thus, the antiapoptotic property of suramin in the liver may be therapeutically exploited. |
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| DOI: | doi:10.1038/nm1049 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/nm1049 |
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| | Volltext: https://www.nature.com/articles/nm1049 |
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| | DOI: https://doi.org/10.1038/nm1049 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1753149401 |
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| Verknüpfungen: | → Zeitschrift |
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Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice / Eichhorst, Sören [VerfasserIn]; 16 May 2004 (Online-Ressource)
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