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| Verfasst von: | Demjen, Deana [VerfasserIn]  |
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| | Kleber, Susanne [VerfasserIn] |
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| | Zuliani, Cecilia [VerfasserIn] |
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| | Stieltjes, Bram [VerfasserIn] |
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| | Walczak, Henning [VerfasserIn] |
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| | Essig, Marco [VerfasserIn] |
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| | Edler, Lutz [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Martín-Villalba, Ana [VerfasserIn] |
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| Titel: | Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury |
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| Verf.angabe: | Deana Demjen, Stefan Klussmann, Susanne Kleber, Cecilia Zuliani, Bram Stieltjes, Corinna Metzger, Ulrich A. Hirt, Henning Walczak, Werner Falk, Marco Essig, Lutz Edler, Peter H. Krammer & Ana Martin-Villalba |
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| E-Jahr: | 2004 |
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| Jahr: | 7 March 2004 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 06.04.2021 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | New York, NY : Nature America Inc., 1995 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 10(2004), 4, Seite 389-395 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | The clinical outcome of spinal cord injury (SCI) depends in part on the extent of secondary damage, to which apoptosis contributes. The CD95 and tumor necrosis factor (TNF) ligand/receptor systems play an essential role in various apoptotic mechanisms. To determine the involvement of these ligands in SCI-induced damage, we neutralized the activity of CD95 ligand (CD95L) and/or TNF in spinal cord-injured mice. Therapeutic neutralization of CD95L, but not of TNF, significantly decreased apoptotic cell death after SCI. Mice treated with CD95L-specific antibodies were capable of initiating active hind-limb movements several weeks after injury. The improvement in locomotor performance was mirrored by an increase in regenerating fibers and upregulation of growth-associated protein-43 (GAP-43). Thus, neutralization of CD95L promoted axonal regeneration and functional improvement in injured adult animals. This therapeutic strategy may constitute a potent future treatment for human spinal injury. |
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| DOI: | doi:10.1038/nm1007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/nm1007 |
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| | Volltext: https://www.nature.com/articles/nm1007 |
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| | DOI: https://doi.org/10.1038/nm1007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1753152259 |
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| Verknüpfungen: | → Zeitschrift |
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Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury / Demjen, Deana [VerfasserIn]; 7 March 2004 (Online-Ressource)
