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Status: Bibliographieeintrag

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Verfasst von:Groth, Christopher [VerfasserIn]   i
 Arpinati, Ludovica [VerfasserIn]   i
 Shaul, Merav E. [VerfasserIn]   i
 Winkler, Nina [VerfasserIn]   i
 Diester, Klara [VerfasserIn]   i
 Gengenbacher, Nicolas [VerfasserIn]   i
 Weber, Rebekka [VerfasserIn]   i
 Arkhypov, Ihor [VerfasserIn]   i
 Lasser, Samantha [VerfasserIn]   i
 Petrova, Vera [VerfasserIn]   i
 Augustin, Hellmut [VerfasserIn]   i
 Altevogt, Peter [VerfasserIn]   i
 Utikal, Jochen [VerfasserIn]   i
 Fridlender, Zvi G. [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
Titel:Blocking migration of polymorphonuclear myeloid-derived suppressor cells inhibits mouse melanoma progression
Verf.angabe:Christopher Groth, Ludovica Arpinati, Merav E. Shaul, Nina Winkler, Klara Diester, Nicolas Gengenbacher, Rebekka Weber, Ihor Arkhypov, Samantha Lasser, Vera Petrova, Hellmut G. Augustin, Peter Altevogt, Jochen Utikal, Zvi G. Fridlender and Viktor Umansky
E-Jahr:2021
Jahr:10 February 2021
Umfang:20 S.
Fussnoten:Gesehen am 07.04.2021
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2021
Band/Heft Quelle:13(2021), 4, Artikel-ID 726, Seite 1-20
ISSN Quelle:2072-6694
Abstract:Background: Despite recent improvement in the treatment of malignant melanoma by immune-checkpoint inhibitors, the disease can progress due to an immunosuppressive tumor microenvironment (TME) mainly represented by myeloid-derived suppressor cells (MDSC). However, the relative contribution of the polymorphonuclear (PMN) and monocytic (M) MDSC subsets to melanoma progression is not clear. Here, we compared both subsets regarding their immunosuppressive capacity and recruitment mechanisms. Furthermore, we inhibited PMN-MDSC migration in vivo to determine its effect on tumor progression. Methods: Using the RET transgenic melanoma mouse model, we investigated the immunosuppressive function of MDSC subsets and chemokine receptor expression on these cells. The effect of CXCR2 inhibition on PMN-MDSC migration and tumor progression was studied in RET transgenic mice and in C57BL/6 mice after surgical resection of primary melanomas. Results: Immunosuppressive capacity of intratumoral M- and PMN-MDSC was comparable in melanoma bearing mice. Anti-CXCR2 therapy prolonged survival of these mice and decreased the occurrence of distant metastasis. Furthermore, this therapy reduced the infiltration of melanoma lesions and pre-metastatic sites with PMN-MDSC that was associated with the accumulation of natural killer (NK) cells. Conclusions: We provide evidence for the tumor−promoting properties of PMN-MDSC as well as for the anti-tumor effects upon their targeting in melanoma bearing mice.
DOI:doi:10.3390/cancers13040726
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/cancers13040726
 Volltext: https://www.mdpi.com/2072-6694/13/4/726
 DOI: https://doi.org/10.3390/cancers13040726
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CXCL1
 CXCR2
 genetically engineered mouse model
 immunosuppression
 immunotherapy
 melanoma
 metastasis
 PMN-MDSC
K10plus-PPN:1753224799
Verknüpfungen:→ Zeitschrift

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