| |  Online-Ressource |
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| Verfasst von: | Egarter, Saskia [VerfasserIn]  |
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| | Santos, Jorge M. [VerfasserIn] |
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| | Kehrer, Jessica [VerfasserIn] |
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| | Sattler, Julia M. [VerfasserIn] |
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| | Frischknecht, Friedrich [VerfasserIn] |
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| | Mair, Gunnar R. [VerfasserIn] |
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| Titel: | Gliding motility protein LIMP promotes optimal mosquito midgut traversal and infection by Plasmodium berghei |
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| Verf.angabe: | Saskia Egarter, Jorge M. Santos, Jessica Kehrer, Julia Sattler, Friedrich Frischknecht, Gunnar R. Mair |
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| Jahr: | 2021 |
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| Jahr des Originals: | 2020 |
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| Umfang: | 4 S. |
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| Fussnoten: | Available online 18 December 2020 ; Gesehen am 08.04.2021 |
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| Titel Quelle: | Enthalten in: Molecular and biochemical parasitology |
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| Ort Quelle: | Amsterdam : Elsevier, 1980 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 241(2021), Artikel-ID 111347, Seite 1-4 |
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| ISSN Quelle: | 1872-9428 |
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| Abstract: | Substrate-dependent gliding motility is key to malaria transmission. It mediates host cell traversal, invasion and infection by Plasmodium and related apicomplexan parasites. The 110 amino acid-long cell surface protein LIMP is essential for P. berghei sporozoites where it is required for the invasion of the mosquito’s salivary glands and the liver cells of the rodent host. Here we define an additional role for LIMP during mosquito invasion by the ookinete. limp mRNA is provided as a translationally repressed mRNP (messenger ribonucleoprotein) by the female gametocyte and the protein translated in the ookinete. Parasites depleted of limp (Δlimp) develop ookinetes with apparent normal morphology and no defect during in vitro gliding motility, and yet display a pronounced reduction in oocyst numbers; compared to wildtype 82 % more Δlimp ookinetes remain within the mosquito blood meal explaining the decrease in oocysts. As in the sporozoite, LIMP exerts a profound role on ookinete infection of the mosquito. |
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| DOI: | doi:10.1016/j.molbiopara.2020.111347 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.molbiopara.2020.111347 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0166685120301110 |
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| | DOI: https://doi.org/10.1016/j.molbiopara.2020.111347 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DOZI |
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| | Gliding motility |
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| | LIMP |
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| | Ookinete |
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| | Translational repression |
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| | Transmission |
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| K10plus-PPN: | 1753268710 |
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| Verknüpfungen: | → Zeitschrift |
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Gliding motility protein LIMP promotes optimal mosquito midgut traversal and infection by Plasmodium berghei / Egarter, Saskia [VerfasserIn]; 2021 (Online-Ressource)
