Lower values of a novel index of vagal-neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up

• Verfasst von: Jarczok, Marc N. [VerfasserIn]
• Verfasst von: Koenig, Julian [VerfasserIn]
• Verfasst von: Thayer, Julian F. [VerfasserIn]
• Titel: Lower values of a novel index of vagal-neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up
• Verf.angabe: Marc N. Jarczok, Julian Koenig & Julian F. Thayer
• E-Jahr: 2021
• Jahr: 28 January 2021
• Umfang: 8 S.
• Fussnoten: Gesehen am 08.04.2021
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2021
• Band/Heft Quelle: 11(2021), Artikel-ID 2554, Seite 1-8
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-021-82168-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1753270685

Abstract

In recent clinical practice, a biomarker of vagal neuroimmunomodulation (NIM), namely the ratio of vagally-mediated heart rate variability (vmHRV) and CRP, was proposed to index the functionality of the cholinergic anti-inflammatory pathway. This study aims to transfer and extend the previous findings to two general population-based samples to explore the hypothesis that NIM-ratio is associated with all-cause mortality. Two large population studies (MIDUS 2: N = 1255 and Whitehall II wave 5: N = 7870) with complete data from a total of N = 3860 participants (36.1% females; average age = 56.3 years; 11.1% deaths, last exit 18.1 years post inclusion) were available. NIM indices were calculated using the vagally-mediated HRV measure RMSSD divided by measures of CRP (NIMCRP) or IL-6 (NIMIL6). The NIM-ratios were quartiled and entered into age, ethnicity and body mass index adjusted Cox proportional hazards models. For NIMIL6 the lowest quartile was 45% more likely to die during the observed period (max. 18 years follow-up) compared to the highest quartile (HR = 0.55 CI 0.41-0.73; p < .0001). NIMCRP parallel these results. Here we show that an easily computable index of IL-6 inhibition is associated with all-cause mortality in two large general population samples. These results suggest that this index might be useful for risk stratification and warrant further examination.