Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Jarolimek, Wolfgang [VerfasserIn]  |
|---|
| | Misgeld, Ulrich [VerfasserIn] |
|---|
| Titel: | Reduction of GABAA receptor-mediated inhibition by the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione in cultured neurons of rat brain |
|---|
| Verf.angabe: | W. Jarolimek and U. Misgeld |
|---|
| Jahr: | 1991 |
|---|
| Umfang: | 4 S. |
|---|
| Teil: | volume:121 |
|---|
| | year:1991 |
|---|
| | number:1 |
|---|
| | pages:227-230 |
|---|
| | extent:4 |
|---|
| Fussnoten: | ImText ist das letzte "A" bei GABAA tiefgestellt ; Online 19 March 2003 ; Gesehen am 08.04.2021 ; Elektronische Reproduktion der Druck-Ausgabe |
|---|
| Titel Quelle: | Enthalten in: Neuroscience letters |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
|---|
| Jahr Quelle: | 1991 |
|---|
| Band/Heft Quelle: | 121(1991), 1, Seite 227-230 |
|---|
| ISSN Quelle: | 1872-7972 |
|---|
| Abstract: | The action of the non-N-methyl-d-aspartate (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on γ-aminobutyric acid-A (GABAA) receptor-mediated currents was studied in dissociated rat midbrain and hypothalamic cultures using whole-cell recording. Spontaneous synaptic activity consisted of excitatory (EPSCs) and inhibitory postsynaptic currents (IPSCs). Bicuculline (20 μM) blocked IPSCs and increased the frequency of EPSCs. CNQX (1 μM) reduced both EPSCs and IPSCs. In the presence of 0.3 μM tetrodotoxin (TTX), CNQX (1-20 μM) blocked miniature EPSCs and reduced IPSCs. In TTX, increasing K+ (20 mM) evoked EPSCs and IPSCs in a Ca-dependent manner. CNQX (10 μM) blocked evoked EPSCs and diminished evoked IPSCs similarly as miniature IPSCs. Muscimol-(0.2-5 μM) induced currents were dose-dependently reduced by CNQX (10-50 μM). It is concluded that CNQX reduces GABAA receptor-mediated inhibition primarily by reducing the excitatory drive in the evolving network, but, in addition, has a significant blocking effect on the GABAA receptor-channel complex. |
|---|
| DOI: | doi:10.1016/0304-3940(91)90691-L |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/0304-3940(91)90691-L |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/030439409190691L |
|---|
| | DOI: https://doi.org/10.1016/0304-3940(91)90691-L |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | CNQX |
|---|
| | GABA |
|---|
| | Hypothalamic culture |
|---|
| | Miniature synaptic current |
|---|
| | Synaptic transmission |
|---|
| | Ventral tegmental culture |
|---|
| K10plus-PPN: | 1753328233 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Reduction of GABAA receptor-mediated inhibition by the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione in cultured neurons of rat brain / Jarolimek, Wolfgang [VerfasserIn]; 1991 (Online-Ressource)
68721228
