Lack of proapoptotic activity of soluble CD95 ligand is due to its failure to induce CD95 oligomers

• Verfasst von: Jang, Sihyug [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Verfasst von: Salgame, Padmini [VerfasserIn]
• Titel: Lack of proapoptotic activity of soluble CD95 ligand is due to its failure to induce CD95 oligomers
• Verf.angabe: Sihyug Jang, Peter H. Krammer, and Padmini Salgame
• Jahr: 2003
• Umfang: 7 S.
• Teil: volume:23
• Teil: year:2003
• Teil: number:8
• Teil: pages:441-447
• Teil: extent:7
• Fussnoten: Published online: 7 Jul 2004 ; Elektronische Reproduktion der Druck-Ausgabe ; Gesehen am 08.04.2021
• Titel Quelle: Enthalten in: Journal of interferon & cytokine research
• Ort Quelle: Larchmont, NY : Liebert, 1995
• Jahr Quelle: 2003
• Band/Heft Quelle: 23(2003), 8, Seite 441-447
• ISSN Quelle: 1557-7465
• DOI: doi:10.1089/107999003322277856
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1753333377

Abstract

CD95 and CD95 ligand (CD95L) are critical molecules of the immune system. They play an important role in regulating T cell apoptosis. The membrane form of CD95L can be cleaved to release a soluble version, which possesses reduced apoptotic activity. In this study, we formally demonstrate that the reduced activity of soluble CD95L is due to its inability to oligomerize the CD95 receptor, an event that is critical for initiating death signaling from the receptor.