Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Brunner, Hans [VerfasserIn]  |
| Misgeld, Ulrich [VerfasserIn]  |
Titel: | Muscarinic amplification of fast excitation in hilar neurones and inhibition in granule cells in the guinea-pig hippocampus |
Verf.angabe: | Hans Brunner and Ulrich Misgeld |
E-Jahr: | 1994 |
Jahr: | 01 November 1994 |
Umfang: | 14 S. |
Teil: | volume:480 |
| year:1994 |
| number:3 |
| pages:513-526 |
| extent:14 |
Fussnoten: | Gesehen am 08.04.2021 |
Titel Quelle: | Enthalten in: The journal of physiology |
Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1878 |
Jahr Quelle: | 1994 |
Band/Heft Quelle: | 480(1994), 3, Seite 513-526 |
ISSN Quelle: | 1469-7793 |
Abstract: | 1. Effects of the cholinergic agonist, carbachol (CCh), or the acetylcholinesterase inhibitor, eserine, on presumed inhibitory hilar neurones and on inhibition in granule cells were studied by intracellular recording in guinea-pig hippocampal slices. 2. CCh (1-5 microM) strongly enhanced the discharge activity of hilar neurones and spontaneous and evoked IPSPs in granule cells. 3. Eserine, in an atropine-sensitive manner, increased the excitability of hilar neurones through effects on membrane properties and on excitatory synaptic barrage. EPSPs readily triggered long-duration burst discharges. In granule cells, the amplitudes of evoked GABAA and GABAB receptor-mediated IPSPs were enhanced. 4. In the presence of eserine and antagonists for glutamatergic and GABAergic synaptic transmission, train stimulation evoked atropine-sensitive slow EPSPs. In contrast to those in granule cells, slow EPSPs in hilar neurones were invariably preceded by a strong burst-after-hyperpolarization. 5. We suggest that acetylcholine, released from septo-hippocampal fibres, amplifies fast synaptic excitation of inhibitory hilar neurones and inhibition of granule cells. In the dentate area, muscarinic receptor-mediated effects are faster than anticipated from the time course of the slow EPSP. |
DOI: | doi:10.1113/jphysiol.1994.sp020380 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1113/jphysiol.1994.sp020380 |
| Volltext: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1994.sp020380 |
| DOI: https://doi.org/10.1113/jphysiol.1994.sp020380 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1753341868 |
Verknüpfungen: | → Zeitschrift |
Muscarinic amplification of fast excitation in hilar neurones and inhibition in granule cells in the guinea-pig hippocampus / Brunner, Hans [VerfasserIn]; 01 November 1994 (Online-Ressource)
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