| Online-Ressource |
Verfasst von: | Kopp, Benedikt [VerfasserIn]  |
| Mein, Stewart [VerfasserIn]  |
| Tessonnier, Thomas [VerfasserIn]  |
| Besuglow, Judith [VerfasserIn]  |
| Harrabi, Semi B. [VerfasserIn]  |
| Heim, Eric [VerfasserIn]  |
| Abdollahi, Amir [VerfasserIn]  |
| Haberer, Thomas [VerfasserIn]  |
| Debus, Jürgen [VerfasserIn]  |
| Mairani, Andrea [VerfasserIn]  |
Titel: | Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM) |
Verf.angabe: | B. Kopp, S. Mein, T. Tessonnier, J. Besuglow, S. Harrabi, E. Heim, A. Abdollahi, T. Haberer, J. Debus, A. Mairani |
E-Jahr: | 2021 |
Jahr: | 19 January 2021 |
Umfang: | 12 S. |
Fussnoten: | Im Titel ist die Zahl 4 hochgestellt ; Gesehen am 09.04.2021 |
Titel Quelle: | Enthalten in: Physica medica |
Ort Quelle: | Amsterdam : Elsevier, 1996 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 81(2021), Seite 273-284 |
ISSN Quelle: | 1724-191X |
Abstract: | Purpose - To develop and verify effective dose (DRBE) calculation in 4He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine. - Methods - Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC) simulations for 4He-ion beams. Relative biological effectiveness (RBE) and DRBE calculation using MRFS were established within a fast analytical engine. Spread-out Bragg-Peaks (SOBPs) in water were optimized for two dose levels and two tissue types with photon linear-quadratic model parameters αph, βph, and (α/β)ph to verify MRFS-derived database implementation against computations with MC-generated mixed-field α and β databases. Bio-sensitivity of the SOBPs was investigated by varying absolute values of βph, while keeping (α/β)ph constant. Additionally, dose, dose-averaged linear energy transfer, and bio-sensitivity were investigated for two patient cases. - Results - Using MRFS-derived databases, dose differences ≲2% in the plateau and SOBP are observed compared to computations with MC-generated databases. Bio-sensitivity studies show larger deviations when altering the absolute βph value, with maximum D50% changes of ~5%, with similar results for patient cases. Bio-sensitivity analysis indicates a greater impact on DRBE varying (α/β)ph than βph in mMKM. - Conclusions - The MRSF approach yielded negligible differences in the target and small differences in the plateau compared to MC-generated databases. The presented analyses provide guidance for proper implementation of RBE-weighted 4He ion dose prescription and planning with mMKM. The MRFS-DRBE calculation approach using mMKM will be implemented in a clinical treatment planning system. |
DOI: | doi:10.1016/j.ejmp.2020.11.028 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ejmp.2020.11.028 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1120179720303033 |
| DOI: https://doi.org/10.1016/j.ejmp.2020.11.028 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biological model |
| FRoG/PRECISE |
| Heidelberg Ion-Beam Therapy Center |
| Helium ion therapy |
K10plus-PPN: | 1753347971 |
Verknüpfungen: | → Zeitschrift |
Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM) / Kopp, Benedikt [VerfasserIn]; 19 January 2021 (Online-Ressource)