Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)

• Verfasst von: Kopp, Benedikt [VerfasserIn]
• Verfasst von: Mein, Stewart [VerfasserIn]
• Verfasst von: Tessonnier, Thomas [VerfasserIn]
• Verfasst von: Besuglow, Judith [VerfasserIn]
• Verfasst von: Harrabi, Semi B. [VerfasserIn]
• Verfasst von: Heim, Eric [VerfasserIn]
• Verfasst von: Abdollahi, Amir [VerfasserIn]
• Verfasst von: Haberer, Thomas [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Mairani, Andrea [VerfasserIn]
• Titel: Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)
• Verf.angabe: B. Kopp, S. Mein, T. Tessonnier, J. Besuglow, S. Harrabi, E. Heim, A. Abdollahi, T. Haberer, J. Debus, A. Mairani
• E-Jahr: 2021
• Jahr: 19 January 2021
• Umfang: 12 S.
• Fussnoten: Im Titel ist die Zahl 4 hochgestellt ; Gesehen am 09.04.2021
• Titel Quelle: Enthalten in: Physica medica
• Ort Quelle: Amsterdam : Elsevier, 1996
• Jahr Quelle: 2021
• Band/Heft Quelle: 81(2021), Seite 273-284
• ISSN Quelle: 1724-191X
• DOI: doi:10.1016/j.ejmp.2020.11.028
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biological model
• Sach-SW: FRoG/PRECISE
• Sach-SW: Heidelberg Ion-Beam Therapy Center
• Sach-SW: Helium ion therapy
• K10plus-PPN: 1753347971

Abstract

Purpose - To develop and verify effective dose (DRBE) calculation in 4He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine. - Methods - Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC) simulations for 4He-ion beams. Relative biological effectiveness (RBE) and DRBE calculation using MRFS were established within a fast analytical engine. Spread-out Bragg-Peaks (SOBPs) in water were optimized for two dose levels and two tissue types with photon linear-quadratic model parameters αph, βph, and (α/β)ph to verify MRFS-derived database implementation against computations with MC-generated mixed-field α and β databases. Bio-sensitivity of the SOBPs was investigated by varying absolute values of βph, while keeping (α/β)ph constant. Additionally, dose, dose-averaged linear energy transfer, and bio-sensitivity were investigated for two patient cases. - Results - Using MRFS-derived databases, dose differences ≲2% in the plateau and SOBP are observed compared to computations with MC-generated databases. Bio-sensitivity studies show larger deviations when altering the absolute βph value, with maximum D50% changes of ~5%, with similar results for patient cases. Bio-sensitivity analysis indicates a greater impact on DRBE varying (α/β)ph than βph in mMKM. - Conclusions - The MRSF approach yielded negligible differences in the target and small differences in the plateau compared to MC-generated databases. The presented analyses provide guidance for proper implementation of RBE-weighted 4He ion dose prescription and planning with mMKM. The MRFS-DRBE calculation approach using mMKM will be implemented in a clinical treatment planning system.