| |  Online-Ressource |
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| Verfasst von: | Rehm, Martin [VerfasserIn]  |
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| | Büchele, Gisela [VerfasserIn] |
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| | Brenner, Rolf Erwin [VerfasserIn] |
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| | Günther, Klaus-Peter [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Koenig, Wolfgang [VerfasserIn] |
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| | Rothenbacher, Dietrich [VerfasserIn] |
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| Titel: | Repeated measurements of cardiac troponin T and N-terminal pro-B-type natriuretic peptide to assess long-term mortality risk in subjects with osteoarthritis |
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| Verf.angabe: | Martin Rehm, Gisela Büchele, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig and Dietrich Rothenbacher |
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| E-Jahr: | 2021 |
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| Jahr: | 5 February 2021 |
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| Umfang: | 12 S. |
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| Teil: | volume:11 |
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| | year:2021 |
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| | number:2 |
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| | elocationid:230 |
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| | pages:1-12 |
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| | extent:12 |
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| Fussnoten: | Gesehen am 08.04.2021 |
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| Titel Quelle: | Enthalten in: Biomolecules |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021), 2, Artikel-ID 230, Seite 1-12 |
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| ISSN Quelle: | 2218-273X |
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| Abstract: | Osteoarthritis (OA) is associated with higher cardiovascular mortality risk. High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well-characterized prognostic cardiac markers. We aimed to describe the changes in biomarkers measured one year apart in a cohort of 347 subjects with OA who underwent hip or knee replacement surgery in 1995/1996 and to analyze the prognostic value of repeated measurements for long-term mortality. During a median follow-up of 19 years, 209 (60.2%) subjects died. Substantial changes in cardiac biomarkers, especially for NT-proBNP, and an independent prognostic value of NT-proBNP for long-term mortality were found for both baseline measurement concentration (hazard ratio (HR) 1.32, 95% confidence interval (CI) (1.13-1.55)) and follow-up measurement concentration (HR 1.39, 95% CI 1.18-1.64) (all HR per standard deviation increase after natural log-transformation). Baseline concentrations were correlated with follow-up concentrations of NT-proBNP and no longer showed prognostic value when included simultaneously in a single model (HR 1.08, 95% CI 0.86-1.37), whereas the estimate for the one-year measurement remained robust (HR 1.31, 95% CI 1.04-1.66). Therefore, no significant additional benefit of repeated NT-proBNP measurements was found in this cohort, facilitating the use of a single NT-proBNP measurement as a stable prognostic marker. |
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| DOI: | doi:10.3390/biom11020230 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/biom11020230 |
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| | Volltext: https://www.mdpi.com/2218-273X/11/2/230 |
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| | DOI: https://doi.org/10.3390/biom11020230 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cohort study |
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| | high-sensitivity cardiac troponin T (hs-cTnT) |
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| | mortality |
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| | N-terminal pro-B-type natriuretic peptide (NT-proBNP) |
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| | osteoarthritis |
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| | repeated measurements |
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| K10plus-PPN: | 1753352029 |
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| Verknüpfungen: | → Zeitschrift |
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Repeated measurements of cardiac troponin T and N-terminal pro-B-type natriuretic peptide to assess long-term mortality risk in subjects with osteoarthritis / Rehm, Martin [VerfasserIn]; 5 February 2021 (Online-Ressource)
