Multidirectional walking in hematopoietic stem cell transplant patients

• Verfasst von: Potiaumpai, Melanie [VerfasserIn]
• Verfasst von: Cutrono, Stacy [VerfasserIn]
• Verfasst von: Medina, Tamia [VerfasserIn]
• Verfasst von: Köppel, Maximillian [VerfasserIn]
• Verfasst von: Pereira, Denise L. [VerfasserIn]
• Verfasst von: Pirl, William F. [VerfasserIn]
• Verfasst von: Jacobs, Kevin A. [VerfasserIn]
• Verfasst von: Eltoukhy, Moataz [VerfasserIn]
• Verfasst von: Signorile, Joseph F. [VerfasserIn]
• Titel: Multidirectional walking in hematopoietic stem cell transplant patients
• Verf.angabe: Melanie Potiaumpai, Stacy Cutrono, Tamia Medina, Maximillian Koeppel, Denise L. Pereira, William F. Pirl, Kevin A. Jacobs, Moataz Eltoukhy, and Joseph F. Signorile
• E-Jahr: 2021
• Jahr: February 2021
• Umfang: 9 S.
• Fussnoten: Gesehen am 08.04.2021
• Titel Quelle: Enthalten in: Medicine and science in sports and exercise
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1969
• Jahr Quelle: 2021
• Band/Heft Quelle: 53(2021), 2, Seite 258-266
• ISSN Quelle: 1530-0315
• DOI: doi:10.1249/MSS.0000000000002474
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1753359309

Abstract

Background - The effect of a peritransplant multidirectional walking intervention to target losses in physical function and quality of life (QOL) has not been investigated. - Purpose - This study examined the effects of a novel multidirectional walking program on physical function and QOL in adults receiving a hematopoietic stem cell transplant (HSCT). - Methods - Thirty-five adults receiving an autologous or allogeneic HSCT were randomized to a multidirectional walking (WALK) or usual care (CONT) group. The WALK group received supervised training during hospitalization; the CONT group received usual care. Patients were assessed at admission (t0), 3 to 5 d post-HSCT (t1), and 30 d post-HSCT (t2). Physical function measures included the 6-min walk test (6MWT), the Physical Performance Test, and the Timed Up and Go test. Health-related QOL was collected using the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire. - Results - There were no significant between-group changes for physical function or QOL. However, after the intervention (t1 to t2), the WALK group showed significant improvement in aerobic capacity (6MWT, P = 0.01), physical (P < 0.01) and functional well-being (P = 0.04), and overall QOL scores (P < 0.01). The CONT group saw no significant changes in physical function or QOL. Effect sizes showed the WALK group had a larger positive effect on physical function and QOL. Minimal clinically important differences in the 6MWT and FACT-BMT were exceeded in the WALK group. - Conclusion - A multidirectional walking program during the transplant period may be effective at increasing aerobic capacity and QOL for patients receiving HSCT compared with no structured exercise.