| |  Online-Ressource |
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| Verfasst von: | Rohde, Marius [VerfasserIn]  |
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| | Richter, Julia [VerfasserIn] |
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| | Schlesner, Matthias [VerfasserIn] |
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| | Betts, Matthew J. [VerfasserIn] |
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| | Claviez, Alexander [VerfasserIn] |
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| | Bonn, Bettina R. [VerfasserIn] |
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| | Zimmermann, Martin [VerfasserIn] |
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| | Damm-Welk, Christine [VerfasserIn] |
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| | Russell, Robert B. [VerfasserIn] |
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| | Borkhardt, Arndt [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| | Höll, Jessica [VerfasserIn] |
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| | Szczepanowski, Monika [VerfasserIn] |
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| | Oschlies, Ilske [VerfasserIn] |
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| | Klapper, Wolfram [VerfasserIn] |
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| | Burkhardt, Birgit [VerfasserIn] |
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| | Siebert, Reiner [VerfasserIn] |
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| Titel: | Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols |
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| Verf.angabe: | Marius Rohde, Julia Richter, Matthias Schlesner, Matthew J. Betts, Alexander Claviez, Bettina R. Bonn, Martin Zimmermann, Christine Damm-Welk, Robert B. Russell, Arndt Borkhardt, Roland Eils, Jessica I. Hoell, Monika Szczepanowski, Ilske Oschlies, Wolfram Klapper, Birgit Burkhardt, Reiner Siebert, on behalf of the German ICGC MMML-Seq-Project and the NHL-BFM Study Group |
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| E-Jahr: | 2014 |
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| Jahr: | 8 July 2014 |
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| Umfang: | 6 S. |
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| Teil: | volume:53 |
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| | year:2014 |
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| | number:11 |
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| | pages:911-916 |
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| | extent:6 |
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| Fussnoten: | Gesehen am 08.04.2021 |
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| Titel Quelle: | Enthalten in: Genes, chromosomes & cancer |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1989 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 53(2014), 11, Seite 911-916 |
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| ISSN Quelle: | 1098-2264 |
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| Abstract: | Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in childhood. Genetically, it is characterized by the presence of an IG-MYC translocation which is supposed to be an initiating but not sufficient event in Burkitt lymphomagenesis. In a recent whole-genome sequencing study of four cases, we showed that the gene encoding the ras homolog family member A (RHOA) is recurrently mutated in pediatric BL. Here, we analyzed RHOA by Sanger sequencing in a cohort of 101 pediatric B-cell lymphoma patients treated according to Non-Hodgkin's Lymphoma Berlin-Frankfurt-Münster (NHL-BFM) study protocols. Among the 78 BLs in this series, an additional five had RHOA mutations resulting in a total incidence of 7/82 (8.5%) with c.14G>A (p.R5Q) being present in three cases. Modeling the mutational effect suggests that most of them inactivate the RHOA protein. Thus, deregulation of RHOA by mutation is a recurrent event in Burkitt lymphomagenesis in children. |
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| DOI: | doi:10.1002/gcc.22202 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/gcc.22202 |
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| | DOI: https://doi.org/10.1002/gcc.22202 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adolescent |
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| | Antineoplastic Combined Chemotherapy Protocols |
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| | Asparaginase |
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| | Burkitt Lymphoma |
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| | Child |
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| | Child, Preschool |
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| | Cohort Studies |
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| | Daunorubicin |
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| | Female |
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| | Humans |
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| | Lymphoma, B-Cell |
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| | Male |
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| | Mutation |
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| | Pediatrics |
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| | Prednisone |
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| | rhoA GTP-Binding Protein |
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| | Vincristine |
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| K10plus-PPN: | 1753381401 |
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| Verknüpfungen: | → Zeitschrift |
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Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols / Rohde, Marius [VerfasserIn]; 8 July 2014 (Online-Ressource)
