Role of endogenous monomethylated L-arginine (L-NMMA) after subarachnoid hemorrhage

• Verfasst von: Jung, Carla Sabine [VerfasserIn]
• Verfasst von: Lange, B. [VerfasserIn]
• Verfasst von: Zimmermann, M. [VerfasserIn]
• Verfasst von: Seifert, Volker [VerfasserIn]
• Titel: Role of endogenous monomethylated L-arginine (L-NMMA) after subarachnoid hemorrhage
• Verf.angabe: Carla S. Jung, B. Lange, M. Zimmermann & Volker Seifert
• E-Jahr: 2013
• Jahr: 03 Dec 2013
• Umfang: 4 S.
• Teil: volume:35
• Teil: year:2013
• Teil: number:7
• Teil: pages:709-712
• Teil: extent:4
• Fussnoten: Gesehen am 09.04.2021
• Titel Quelle: Enthalten in: Neurological research
• Ort Quelle: Abingdon, Oxon : Taylor & Francis, 1979
• Jahr Quelle: 2013
• Band/Heft Quelle: 35(2013), 7, Seite 709-712
• ISSN Quelle: 1743-1328
• DOI: doi:10.1179/1743132813Y.0000000194
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Delayed cerebral ischemia
• Sach-SW: L-NMMA
• Sach-SW: Subarachnoid hemorrhage
• Sach-SW: Vasospasm
• K10plus-PPN: 1753559650

Abstract

Objectives: Monomethylated L-arginine (L-NMMA) has been proven to be a strong inhibitor of nitric oxide synthase (NOS) and has been used as an exogenous tool in experimental evaluation of cerebrovascular reactivity leading to vasoconstriction. However, L-NMMA is also produced endogenously and belongs, as does asymmetric dimethylated L-arginine (ADMA), to a family of endogenous NOS inhibitors. While ADMA has been associated with cerebral vasospasm (CVS) but not with delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH), no results are available concerning endogenous L-NMMA and SAH. We therefore decided to investigate the role of endogenous L-NMMA with regard to CVS and DCI after SAH.Methods: Retrospective analysis of cerebro-spinal fluid (CSF) and serum of SAH patients and controls was performed by high performance liquid chromatography (HPLC) and chemiluminescence. Delayed CVS was detected by arteriography and cerebral ischemic events by follow-up computed tomography (CT) scans.Results: Cerebro-spinal fluid and serum L-NMMA concentrations neither correlated with CVS nor with NO2− levels (P > 0·05, in both cases). However, endogenous L-NMMA concentrations correlated with cerebral ischemic events and with the size of infarction (cc = 0·459, P = 0·032, 95% CI: 0·046-0·738).Conclusions: This study shows that endogenous L-NMMA is associated with the occurrence of cerebral ischemic events, but seems not to be involved in CVS after SAH. Therefore, endogenous L-NMMA after SAH features intriguing differences compared with previous reports on exogenous L-NMMA and ADMA after SAH.