Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Nickel, Sabrina [VerfasserIn]  |
| Mahringer, Anne [VerfasserIn]  |
Titel: | The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats |
Verf.angabe: | Sabrina Nickel, Anne Mahringer |
E-Jahr: | 2014 |
Jahr: | 19 Jun 2014 |
Umfang: | 9 S. |
Teil: | volume:44 |
| year:2014 |
| number:11 |
| pages:1046-1054 |
| extent:9 |
Fussnoten: | Gesehen am 09.04.2021 |
Titel Quelle: | Enthalten in: Xenobiotica |
Ort Quelle: | Abingdon : Taylor & Francis Group, 1971 |
Jahr Quelle: | 2014 |
Band/Heft Quelle: | 44(2014), 11, Seite 1046-1054 |
ISSN Quelle: | 1366-5928 |
Abstract: | 1. Breast cancer resistance protein (BCRP) is an ABC-transporter at the blood-brain barrier (BBB) facilitating efflux of xenobiotics into blood. Expression and function are regulated via estrogen-receptors (ERs).2. 17α-Ethinylestradiol (EE2) and bisphenol A (BPA) represent two prominent xenoestrogens. We studied whether EE2 and BPA regulate BCRP function and expression upon a 6 h treatment in an ER-dependent manner in a rat BBB-ex-vivo-model.3. Isolated brain capillaries were incubated with EE2 or BPA. BCRP function and expression were analyzed by confocal microscopy and Western-Blot. ERα-antagonist MPP and ER-antagonist ICI182.780 were used to study involvement of ERs.4. EE2 and BPA down-regulated BCRP transport function and expression. EE2 effects occurred at pharmacologically relevant doses, BPA exhibited only weak influences. Down-regulation by EE2 was reversed by ICI but not MPP. BPA effects were not reversed by either antagonist.5. EE2 is a potent regulator of BCRP expression and function acting by ERβ-stimulation. Oral contraception could alter uptake of pharmaceuticals to the brain and might thus be considered as an origin of central nervous system (CNS) side-effects. EE2 could also present a novel co-treatment to improve CNS-pharmacotherapy. BPA is a weak modulator of BCRP expression. Its effects appear not to be caused by ERs. |
DOI: | doi:10.3109/00498254.2014.922226 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3109/00498254.2014.922226 |
| DOI: https://doi.org/10.3109/00498254.2014.922226 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 17α-Ethinylestradiol |
| bisphenol A |
| blood-brain barrier |
| breast cancer resistance protein |
| xenoestrogen |
K10plus-PPN: | 1753563259 |
Verknüpfungen: | → Zeitschrift |
¬The¬ xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats / Nickel, Sabrina [VerfasserIn]; 19 Jun 2014 (Online-Ressource)
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