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Verfasst von:Nickel, Sabrina [VerfasserIn]   i
 Mahringer, Anne [VerfasserIn]   i
Titel:The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats
Verf.angabe:Sabrina Nickel, Anne Mahringer
E-Jahr:2014
Jahr:19 Jun 2014
Umfang:9 S.
Teil:volume:44
 year:2014
 number:11
 pages:1046-1054
 extent:9
Fussnoten:Gesehen am 09.04.2021
Titel Quelle:Enthalten in: Xenobiotica
Ort Quelle:Abingdon : Taylor & Francis Group, 1971
Jahr Quelle:2014
Band/Heft Quelle:44(2014), 11, Seite 1046-1054
ISSN Quelle:1366-5928
Abstract:1. Breast cancer resistance protein (BCRP) is an ABC-transporter at the blood-brain barrier (BBB) facilitating efflux of xenobiotics into blood. Expression and function are regulated via estrogen-receptors (ERs).2. 17α-Ethinylestradiol (EE2) and bisphenol A (BPA) represent two prominent xenoestrogens. We studied whether EE2 and BPA regulate BCRP function and expression upon a 6 h treatment in an ER-dependent manner in a rat BBB-ex-vivo-model.3. Isolated brain capillaries were incubated with EE2 or BPA. BCRP function and expression were analyzed by confocal microscopy and Western-Blot. ERα-antagonist MPP and ER-antagonist ICI182.780 were used to study involvement of ERs.4. EE2 and BPA down-regulated BCRP transport function and expression. EE2 effects occurred at pharmacologically relevant doses, BPA exhibited only weak influences. Down-regulation by EE2 was reversed by ICI but not MPP. BPA effects were not reversed by either antagonist.5. EE2 is a potent regulator of BCRP expression and function acting by ERβ-stimulation. Oral contraception could alter uptake of pharmaceuticals to the brain and might thus be considered as an origin of central nervous system (CNS) side-effects. EE2 could also present a novel co-treatment to improve CNS-pharmacotherapy. BPA is a weak modulator of BCRP expression. Its effects appear not to be caused by ERs.
DOI:doi:10.3109/00498254.2014.922226
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3109/00498254.2014.922226
 DOI: https://doi.org/10.3109/00498254.2014.922226
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:17α-Ethinylestradiol
 bisphenol A
 blood-brain barrier
 breast cancer resistance protein
 xenoestrogen
K10plus-PPN:1753563259
Verknüpfungen:→ Zeitschrift

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